Varying intensity of simulated infection partially affects the magnitude of the acute‐phase immune response in the subterranean rodent Ctenomys talarum
Abstract:The acute phase response (APR), coordinated by a complex network of components of the immune and neuroendocrine systems, plays a key role in early immune defense. This response can be elicited by a wide variety of pathogens at different intensities (frequencies and doses), hence experimental immune challenges with antigen gradients makes it possible to evaluate sickness progression with a better representation of what occurs in natural systems. However, how infection intensity could shape the APR magnitude in … Show more
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