Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus)

Nystrom, Gunnar S.; Ellsworth, Schyler A.; Ward, Micaiah J.; Rokyta, Darin R.

doi:10.1007/s00239-023-10148-7

J Mol Evol

2023

DOI: 10.1007/s00239-023-10148-7

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Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus)

Gunnar S. Nystrom,

Schyler A. Ellsworth,

Micaiah J. Ward

et al.

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2024

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Cited by 3 publications

References 106 publications

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Selection Across the Three-Dimensional Structure of Venom Proteins from North American Scolopendromorph Centipedes

Ellsworth,

Rautsaw,

Ward

et al. 2024

J Mol Evol

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Selection Across the Three-Dimensional Structure of Venom Proteins from North American Scolopendromorph Centipedes

Ellsworth,

Rautsaw,

Ward

et al. 2024

J Mol Evol

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Divergence in toxin antigenicity and venom enzymes in Tityus melici, a medically important scorpion, despite transcriptomic and phylogenetic affinities with problematic Brazilian species

Kalapothakis,

Miranda,

Aragão

et al. 2024

International Journal of Biological Macromolecules

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Optimizing Scorpion Toxin Processing through Artificial Intelligence

Psenicnik,

Ojanguren-Affilastro,

Graham

et al. 2024

Toxins

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Scorpion toxins are relatively short cyclic peptides (<150 amino acids) that can disrupt the opening/closing mechanisms in cell ion channels. These peptides are widely studied for several reasons including their use in drug discovery. Although improvements in RNAseq have greatly expedited the discovery of new scorpion toxins, their annotation remains challenging, mainly due to their small size. Here, we present a new pipeline to annotate toxins from scorpion transcriptomes using a neural network approach. This pipeline implements basic neural networks to sort amino acid sequences to find those that are likely toxins and thereafter predict the type of toxin represented by the sequence. We anticipate that this pipeline will accelerate the classification of scorpion toxins in forthcoming scorpion genome sequencing projects and potentially serve a useful role in identifying targets for drug development.

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Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus)

Cited by 3 publications

References 106 publications

Selection Across the Three-Dimensional Structure of Venom Proteins from North American Scolopendromorph Centipedes

Selection Across the Three-Dimensional Structure of Venom Proteins from North American Scolopendromorph Centipedes

Divergence in toxin antigenicity and venom enzymes in Tityus melici, a medically important scorpion, despite transcriptomic and phylogenetic affinities with problematic Brazilian species

Optimizing Scorpion Toxin Processing through Artificial Intelligence

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