VascuFit: vascular effects of non-linear periodized exercise training in sedentary adults with elevated cardiovascular risk – protocol for a randomized controlled trial

Königstein, Karsten; Meier, Jennifer; Angst, Thomas; Maurer, Debbie J; Kröpfl, Julia M.; Carrard, Justin; Infanger, Denis; Baumann, Sandra; Bischofsberger, Imerio; Harder, Marc; Jäggi, Yves; Wettach, Sabrina; Hanssen, Henner; Schmidt‐Trucksäss, Arno

doi:10.1186/s12872-022-02905-1

Cited by 2 publications

(3 citation statements)

References 113 publications

(128 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resistance exercise training: A positive association between the frequency of r sistance training sessions and improvement of endothelial function has been shown [7 As with aerobic exercise training, frequently repeated shorter bouts of exercise traini might be a considerable option in resistance training as well to minimize injury risk. Ho ever, the optimal frequency of training stimuli is still unclear in both aerobic and r sistance exercise training.…”

Section: F-i-t-t Principle: F(requency)mentioning

confidence: 99%

“…By providing some variations to F-I-T-T in a patient-centered, flexible, and individual approach, training may be better tolerated, physically and mentally, than traditional linear training methods. Therefore, methods like nonlinear periodized exercise may promote patients' adherence to exercise therapy while being equally effective as high-intensity or moderate-intensity continuous training [6,7,96,97].…”

Section: Individualizationmentioning

confidence: 99%

“…However, the effectiveness of exercise interventions on biomarkers of vascular health is often limited and not sustainable in the long-term after the discontinuation of exercise training. Targeted exercise, based on objective and subjective individual criteria, carries the potential to overcome these limitations [6,7]. Accordingly, a better understanding of the molecular mechanisms underlying the acute responses and long-term adaptations of the vascular organ to exercise will lead to the design of more effective exercise programs, with better adherence by participants to lifelong training, and potentially will result in a better clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Training the Vessels: Molecular and Clinical Effects of Exercise on Vascular Health—A Narrative Review

Königstein,

Dipla,

Zafeiridis

2023

Cells

Self Cite

View full text Add to dashboard Cite

Accelerated biological vascular ageing is still a major driver of the increasing burden of cardiovascular disease and mortality. Exercise training delays this process, known as early vascular ageing, but often lacks effectiveness due to a lack of understanding of molecular and clinical adaptations to specific stimuli. This narrative review summarizes the current knowledge about the molecular and clinical vascular adaptations to acute and chronic exercise. It further addresses how training characteristics (frequency, intensity, volume, and type) may influence these processes. Finally, practical recommendations are given for exercise training to maintain and improve vascular health. Exercise increases shear stress on the vascular wall and stimulates the endothelial release of circulating growth factors and of exerkines from the skeletal muscle and other organs. As a result, remodeling within the vascular walls leads to a better vasodilator and -constrictor responsiveness, reduced arterial stiffness, arterio- and angiogenesis, higher antioxidative capacities, and reduced oxidative stress. Although current evidence about specific aspects of exercise training, such as F-I-T-T, is limited, and exact training recommendations cannot be given, some practical implications can be extracted. As such, repeated stimuli 5–7 days per week might be necessary to use the full potential of these favorable physiological alterations, and the cumulative volume of mechanical shear stress seems more important than peak shear stress. Because of distinct short- and long-term effects of resistance and aerobic exercise, including higher and moderate intensities, both types of exercise should be implemented in a comprehensive training regimen. As vascular adaptability towards exercise remains high at any age in both healthy individuals and patients with cardiovascular diseases, individualized exercise-based vascular health prevention should be implemented in any age group from children to centenarians.

show abstract

Section: F-i-t-t Principle: F(requency)mentioning

confidence: 99%