2000
DOI: 10.1016/s0735-1097(00)00706-3
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Vascular adhesion protein-1, intercellular adhesion molecule-1 and P-Selectin mediate leukocyte binding to ischemic heart in humans

Abstract: Human P-selectin, ICAM-1 and VAP-1 appear to be the most promising targets when antiadhesive interventions preventing leukocyte-mediated tissue destruction after myocardial ischemia are planned.

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Cited by 73 publications
(48 citation statements)
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“…7 Here we have, for the first time, been able to analyze the role of SSAO activity in vivo. Our results indicate that VAP-1 and its enzymatic activity are important for PMN recruitment to the inflamed air pouch in rats.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…7 Here we have, for the first time, been able to analyze the role of SSAO activity in vivo. Our results indicate that VAP-1 and its enzymatic activity are important for PMN recruitment to the inflamed air pouch in rats.…”
Section: Discussionmentioning
confidence: 99%
“…7 The cells were kept in Hanks Supported by the Finnish Academy, the Sigrid Juselius Foundation, the Technology Development Centre of Finland, the Finnish Cultural Foundation, and the European Union (QLG1-CT-1999-00295).…”
Section: Cells Dna Constructs and Adenoviral Transfectionsmentioning
confidence: 99%
“…This may lead to endothelial activation and induction of VAP-1. 41 VAP-1 may then be involved in enhanced recruitment of monocytes [42][43][44][45] and Th1 CD4 cells 46 into the vessel wall. VAP-1-generated hydrogen peroxide also induces expression of classical endothelial adhesion molecules (P-selectin, MAdCAM-1), chemokines (CXCL8), and inflammatory transcription factors (nuclear factor-B, p53), 9 -11,47 and at high concentrations can be directly cytotoxic.…”
Section: Discussionmentioning
confidence: 99%
“…The molecular weight of human VAP-1 is distinct in different organs and even in one organ under pathological conditions. 25 The changes are believed to be because of alterations in carbohydrate structures of the molecules that are essential for the adhesive function of VAP-1. 9 Indeed, in canine and porcine tissues the molecular weight close to that of human VAP-1 and the expression pattern of the antigen detected in immunohistochemistry in both species together suggest that the molecules recognized by mAb 1B2 in canine and porcine tissues really are the homologues of human VAP-1.…”
Section: Discussionmentioning
confidence: 99%