Vascular and Autonomic Function in Preschool-aged Children with Congenital Heart Disease

Currie, Katharine D.; Martin, Audra A.; Millar, Philip J.; Stone, Nicola D.; Timmons, Brian W.; Dillenburg, Rejane; MacDonald, Maureen J.

doi:10.1111/j.1747-0803.2012.00664.x

Cited by 10 publications

(4 citation statements)

References 33 publications

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“…This observation has also been replicated in adults without chronic disease . One prior study in preschool‐aged children with CHD revealed no indication of increased arterial stiffness, whereas similarly aged school‐age children with CHD as in our study have been shown to have increased arterial stiffness compared to healthy controls . Therefore, children with CHD are more prone to increased arterial stiffness, but the role of physical activity on arterial stiffness has not been previously investigated.…”

Section: Discussionsupporting

confidence: 77%

Physical activity modulates arterial stiffness in children with congenital heart disease: A CHAMPS cohort study

Boyes

Stickland

Fusnik

et al. 2018

Congenital Heart Disease

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Section: Discussionsupporting

confidence: 77%

Physical activity modulates arterial stiffness in children with congenital heart disease: A CHAMPS cohort study

Boyes

Stickland

Fusnik

et al. 2018

Congenital Heart Disease

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“…Unfortunately, this study did not differentiate between types of CHD, age groups, chosen procedures (e.g., transcutaneous or via sternotomy/thoracotomy), untreated or postoperative course, pressure and/or volume overload, presence of heart failure or pulmonary vascular disease, or different long-term courses affecting autonomic nervous system function. Similar drawbacks exist in other small studies on this topic [14,[20][21][22][23][24].…”

Section: Time-frequency Domain Parameterssupporting

confidence: 55%

Continuous Long-Term Assessment of Heart Rate Variability in Adults with Cyanotic Congenital Heart Disease after Surgical Repair

Pieringer,

Suleiman,

Kaemmerer-Suleiman

et al. 2024

JCM

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Background: Heart rate variability (HRV) is an established, non-invasive parameter for the assessment of cardiac autonomic nervous activity and the health status in general cardiology. However, there are few studies on HRV in adults with congenital heart defects (CHDs). The aim of the present study was to evaluate the use of long-term continuous HRV measurement for the assessment of global health status in adults with cyanotic CHD. Methods: This prospective study included 45 adults (40% female, mean age = 35.2 ± 9.2 [range: 19–58] years) after cardiac surgical repair. HRV parameters were calculated from continuous 24 h measurements using a Bittium Faros 180 sensor (Bittium Corp., Oulu, Finland). Results: Postoperative patients with transposition of the great arteries (TGA) (n = 18) achieved significantly higher values of standard deviation of NN intervals (SDNN) (175.4 ± 59.9 ms vs. 133.5 ± 40.6 ms; p = 0.013) compared with patients with other conotruncal anomalies (n = 22). Comparing patients with TGA after a Senning–Brom or Mustard operation (n = 13) with all other heart surgery patients (n = 32), significantly higher HRV parameters were found after atrial switch (root mean square of successive RR interval differences: 53.6 ± 20.7 ms vs. 38.4 ± 18.3 ms; p = 0.019; SDNN: 183.5 ± 58.4 ms vs. 136.3 ± 45.3 ms; p = 0.006). A higher SDNN was also measured after Senning–Brom or Mustard operations than after a Rastelli operations (n = 2) (SDNN: 183.5 ± 58.4 ms vs. 84.5 ± 5.2 ms; p = 0.037). When comparing atrial switch operations (n = 3) with Rastelli operations, the SDNN value was significantly shorter in the Rastelli group (p = 0.004). Conclusions: Our results suggest that continuous HRV monitoring may serve as a marker of cardiac autonomic dysfunction in adults with cyanotic CHD after surgical repair. Impaired cardiac autonomic nervous activity may be associated with an increased risk of adverse reactions in patients with repaired CHD. Therefore, a longitudinal assessment of HRV patterns and trends may provide a deeper insight into dynamic changes in their autonomic regulation and disease progression, lifestyle changes, or treatments. As each person has individual variability in heart rate, HRV may be useful in assessing intra-individual disease progression and may help to improve personalized medicine. Further studies are needed to better understand the underlying mechanisms and to explore the full potential of HRV analysis to optimize medical care for ACHDs.

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“…However, there was no difference in carotid-femoral PWV between patients with repaired TOF and controls in de Groot's study (25). In addition, Currie and colleagues also reported that whole-body PWV (heart-dorsal pedal artery in the study) was not elevated in children with TOF and aortic coarctation (26). Tronjnarska and colleagues reported that carotid-femoral PWV in adult cyanotic patients with CHD was elevated (7.40±2.07 vs. 6.33±0.76 m/s, P=0.003) (27).…”

Section: Pwv In Patients With Chdmentioning

confidence: 83%

Vascular aging in adult congenital heart disease-a narrative review

Murakami¹

2022

Cardiovasc Diagn Ther

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Background and Objective: Many studies about the high prevalence of cardiovascular disease in adults with congenital heart disease (CHD) have been published in response to the growing number of adult patients with CHD. The aging process leads to hypertension and cardiovascular disease, which is caused by a degenerative change in the systemic arterial system characterized by the stiffening of elastic arteries (known as arteriosclerosis) and the enlargement of aorta. In patients with CHD, aortic dilatation (so-called aortopathy) is one of the most frequent complications. It is well known the anatomical and histological changes in aortopathy are similar to those in aging process. The increase of pulse wave velocity (PWV) enhances pressure wave reflection, and it augments left ventricular afterload and impairs the coronary supply-workload balance in aging. This article reviews the aortic function in patients with CHD, aiming to provide a new direction for the management of their cardiovascular aging process.

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Vascular and Autonomic Function in Preschool-aged Children with Congenital Heart Disease

Abstract: These results may indicate that preschool-aged children with repaired CHD display early signs of vascular remodeling, but not autonomic or vascular dysfunction. The effects of larger wall/lumen ratios on cardiovascular disease risk require further investigation.

Cited by 10 publications

References 33 publications

Physical activity modulates arterial stiffness in children with congenital heart disease: A CHAMPS cohort study

Physical activity modulates arterial stiffness in children with congenital heart disease: A CHAMPS cohort study

Continuous Long-Term Assessment of Heart Rate Variability in Adults with Cyanotic Congenital Heart Disease after Surgical Repair

Vascular aging in adult congenital heart disease-a narrative review

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