1988
DOI: 10.1002/ddr.430150103
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Vascular and cardiac effects of HP 406 and nifedipine in vitro and in conscious spontaneously hypertensive rats and renal hypertensive dogs

Abstract: S. Fielding: Vascular and cardiac effects of HP 406 and nifedipine in vitro and in conscious spontaneously hypertensive rats and renal hyptertensive dogs. Drug Dev. Res. 1517Res. -29, 1988.The cardiovascular effects of the calcium antagonists HP 406 and nifedipine were assessed in a series of in vitro and in vivo studies. HP 406 was found to display moderate affinity for dihydropyridine binding sites, as determined by the inhibition of [3H]-nitrendipine binding on rat ventricular membranes. HP 406 was found t… Show more

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