Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats

Abstract

The effects of chronic administration of piceatannol-enriched (9.5% w/w) passion fruit seed extract (PFSE) on the cardiovascular damage induced in a high-fat (HF) diet-fed model of Fischer 344 rats were evaluated. Rats were fed the control, HF, or HF diets containing PFSE (0.5% w/w) for 16 weeks, and the effects of the various diets on the tissue weight, serum lipid profile, hepatic fibrosis, hepatic ductular reaction, cardiac function and aortic ring reactivity were examined. HF diet-fed rats developed signs of cardiovascular disease with abnormal serum profiles compared to control diet-fed rats. PFSE supplementation improved the liver hypertrophy and hepatic histology of the HF diet-fed rats. In addition, the triglyceride and cholesterol levels, platelet aggregation, cardiac function, and acetylcholine-mediated relaxation of the aortic ring were improved. These results suggest that the chronic intake of PFSE containing piceatannol prevents HF diet-induced cardiovascular disease in rats.

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

“…In ethanol-induced liver injury, treated daily with fruit juices to mice for 15 days could protect ethanol-induced liver injury by decreasing AST and ALT in liver, and alleviating the inflammation, oxidative stress (Zhang et al, 2016). In addition, the passion fruit seed extract prevented non-alcoholic fatty liver disease by improving the liver hypertrophy and hepatic histology of the high-fat diet-fed rats (Ishihata et al, 2016). In a pulmonary fibrosis of C57BL/6J mice model induced by bleomycin, administration of passion fruit peel extract significantly reduced loss of body weight and mortality rate, decreased the count of inflammatory cells, macrophages, lymphocytes, and neutrophils, reduced MPO activity and restored bleomycin induced depletion of SOD activity.…”

Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I–mediated cancer cell growth

“…Piceatannol, a stilbene abundantly found in passion fruit seeds, reportedly exhibits a variety of biological activities [23]. Recently, we reported that the piceatannol in PFSE prevents high fat diet–induced cardiovascular disease and promotes neural stem cell differentiation to astrocytes [45,46]. In addition, the antiproliferative effects of piceatannol against some cancer cells have been well studied, and several pathways leading to piceatannol-induced apoptosis have been elucidated [21].…”

The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes

“…More recently, it has been reported that piceatannol can also limit fat deposition in Caenorhabditis elegans [ 30 ] and in mice fed a high-fat diet [ 31 ]. Additional reports have also been published on piceatannol’s ability to lower circulating lipids in the spontaneously obese Zucker rats [ 11 ] and in high-fat diet fed Fisher rats [ 32 ], although without reducing their body weight gain. Thus, piceatannol, structurally similar to resveratrol but less studied for its anti-obesity actions, exhibits potential interest to limit the development of fat stores in vivo.…”