“…This way, NaIHS through direct inhibition of COX-2, would negatively modulate VEGF, 40,42 bFGF, 40,42 HGF, 27 CCL2, 27 ERK2, 40 MAPK, 40 CDK 1/2, 40 CHK1, 40 cyclin A 40 and via Apelin/APJ 40 and, by COX-independent effects, NaIHS would inhibit HIF-1 alpha (HIF-1α) 37 and HIF-2α, 43 thereby it may inhibit pulmonary angiogenesis, 27,37,40,42,43 fibrosis 27,37,41,42,43 and fibrotic sequelae. 27,37,41,42,43 Furthermore, it is important to mention that for other authors, some of the mentioned antiangiogenic effects of ibuprofen may be COX-independent effects 11,43,44 such as VEGF, 11 ERK2, 44 MAPK, 44 CDK 1/2, 44 CHK1, 44 cyclin A 44 and others.…”