Vascular Architecture of Melanocytic Skin Tumors

Smolle, Josef; Soyer, H. P.; Hofmann-Wellenhof, R; Smolle‐Juettner, Freyja‐Maria; Kerl, Helmut

doi:10.1016/s0344-0338(89)80230-4

Cited by 42 publications

(5 citation statements)

References 6 publications

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“…Our observations are in accordance with the results of Smolle et al [43]. They examined 11 cases each of benign nevocellular nevus, primary malignant melanoma and metastatic malignant melanoma.…”

Section: Discussionsupporting

confidence: 93%

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MIB-1 Immunoreactivity Correlates with Blood Vessel Density and Survival in Disseminated Malignant Melanoma

Vlaykova

Talve²,

Hahka‐Kemppinen³

et al. 1999

Oncology

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The purpose of our current work was to evaluate the prognostic significance of tumor cell proliferation in advanced metastatic melanomas and to investigate a possible correlation between the proliferation index and blood vessel density in metastatic tissue. Sixty patients with disseminated malignant melanoma treated with four-drug chemotherapy combined with interferon-α were included in this study. Proliferative activity and vascularity in metastatic tissues were examined by immunohistochemistry with anti-Ki-67 (MIB-1) and anti-CD31 antibody, respectively. A significant relationship between MIB-1 index and blood vessel number was detected (rho = 0.323, p = 0.013). In survival analysis, the overall survival and disease-free survival were significantly longer (58 and 38 vs. 38 and 17 months) for patients with low MIB-1 immunoreactivity (p = 0.012 and p = 0.023, respectively). Likewise, the low MIB-1 labeling index was associated with the prolonged survival calculated from the initiation of the chemoimmunotherapy (12 vs. 7 months, p = 0.032). In multivariate Cox’s proportional hazard analysis, MIB-1 positivity was an independent prognostic factor both for overall survival and for survival after beginning of the chemoimmunotherapy (p = 0.016 and p = 0.029).

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Section: Discussionsupporting

confidence: 93%

“…To our knowledge, only few studies have explored the relationship between proliferative activity and vascularity in malignant melanoma [17, 43]. Our observations are in accordance with the results of Smolle et al [43].…”

Section: Discussionsupporting

confidence: 92%

MIB-1 Immunoreactivity Correlates with Blood Vessel Density and Survival in Disseminated Malignant Melanoma

Vlaykova

Talve²,

Hahka‐Kemppinen³

et al. 1999

Oncology

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“…In contrast to dermoscopy, vascular structure identification and quantification in histopathology brings a smaller benefit for diagnosing these tumors, as the vertical sections of the tissue do not allow observation of the entire structure of the vasculature. It is, therefore, overwhelming, that most studies on skin tumor vascularization refer to statistical analyses of findings in histologic sections, such as microvessel density (131,132). RCM on the other hand, has the advantage of real-time observation of vasculature and blood flow.…”

Section: Discussionmentioning

confidence: 99%

Vascular patterns in basal cell carcinoma: Dermoscopic, confocal and histopathological perspectives (Review)

et al. 2019

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Basal cell carcinoma (BCC) is the most prevalent skin cancer in the Caucasian population. A variety of different phenotypic presentations of BCC are possible. Although BCCs rarely metastasize, these tumors commonly destroy underlying tissues and should therefore be treated promptly. As vascular formation and angiogenesis are indicators of tumor development and progression, the presence of blood vessels, their morphology and architecture are important markers in skin lesions, providing critical information towards pathogenesis and diagnosis. BCC commonly lacks pigmentation, therefore it is important to emphasize the usefulness of vascular feature detection, recognition, quantification and interpretation. To answer the question of whether vascular patterns observed on dermoscopy, reflectance confocal microscopy (RCM) and histopathology might reflect the biologic behavior of BCCs, we undertook this review article. Several studies have sought, by various means, to identify vascular features associated with the more aggressive BCC phenotypes. Dermoscopic vascular pattern assessment can facilitate diagnostic discrimination between BCC subtypes, more aggressive BCCs displaying less or no pink coloration and a relative absence of central tumor vessels. RCM, a novel, non-invasive imaging technique, allows for the quantification of blood vessel size, density, and flow intensity in BCCs. BCCs are distinguished on RCM chiefly by vessels that branch and intertwine between neoplastic aggregates, a pattern strongly reflecting tumor neo-angiogenesis. The analysis of these vascular morphological and distribution patterns can provide further support in the diagnosis, assessment, or monitoring of BCCs. Histopathology shows significantly higher microvessel densities in the peritumoral stroma of BCCs, when compared to normal skin or benign tumors. This angiogenic response in the stroma is associated with local aggressiveness, therefore the quantification of peritumoralmicrovessels may further assist with tumor evaluation. How dermoscopy and RCM vascular patterns in BCC correlate with histopathological subtype and thus help in discriminating aggressive subtypes definitely deserves further investigation.

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“…The vascular morphology of tumours is different within tumours of similar and different histological types (34). It has been suggested that particular vascular patterns might help distinguish benign from malignant lesions (149, 150). Furthermore, a closed back‐to‐back loop vascular pattern has been reported to be a poor prognostic marker in ocular melanomas (151) and in lung carcinomas distinct patterns of neovascularisation have the potential to identify patients who will respond differently to anti‐cancer treatments (14, 15, 152).…”

Section: Tumour Vascular Architecturementioning

confidence: 99%

Histological quantitation of tumour angiogenesis

Fox¹,

Harris

2004

APMIS

126

100

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Tumours establish their blood supply via a number of processes in addition to angiogenesis. These include vasculogenesis, vascular remodelling, intussusception and possibly vascular mimicry in certain tumours. The mainstay of the assessment of tumour vascularity has been counting the number of immunohistochemically identified microvessels in vascular hot spots. Nevertheless, several other techniques are available, including Chalkley counting, vascular grade and the use of image analysis systems. Angiogenic activity can furthermore be assessed in histological samples by measuring the molecules involved in the establishment of the tumour vasculature, including angiogenic growth factors and their receptors, cell adhesion molecules, proteases and markers of activated, proliferating, cytokine stimulated or angiogenic vessels, such as CD105. Measuring the maturity of vessels may give an indication of the proportion of the tumour vasculature that is functional. Other reagents that can identify hypoxia-activated pathways are also being developed. The histological assessment of tumour vascularity is mainly used in the research setting but may also have applications in the clinic if appropriate methodology and trained observers perform the studies. Gene arrays may be able to provide an angiogenesis profile. Continued study into the processes involved in generating a tumour blood supply is likely to identify new markers that may be more accurate measures.

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Vascular Architecture of Melanocytic Skin Tumors

Cited by 42 publications

References 6 publications

MIB-1 Immunoreactivity Correlates with Blood Vessel Density and Survival in Disseminated Malignant Melanoma

MIB-1 Immunoreactivity Correlates with Blood Vessel Density and Survival in Disseminated Malignant Melanoma

Vascular patterns in basal cell carcinoma: Dermoscopic, confocal and histopathological perspectives (Review)

Histological quantitation of tumour angiogenesis

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