Vascular calcification and fracture risk

Szulc, Paweł

doi:10.11138/ccmbm/2015.12.2.139

Cited by 14 publications

(12 citation statements)

References 45 publications

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“…(13)(14)(15)(16) One potential mechanism includes lower oxidative stress by this diet, partly via increased intake of foods rich in antioxidant vitamins. (12,17) Cardiovascular disease is strongly associated with increased risk of fracture, (18) and especially hip fracture. (19) Increased risks of fracture, osteoporosis, and sarcopenia have also been observed both with lower intakes and lower serum levels of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet and Hip Fracture in Swedish Men and Women

Byberg

Bellavia

Larsson

et al. 2016

Journal of Bone and Mineral Research

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A Mediterranean diet, known to have beneficial effects on cardiovascular health, may also influence the risk of hip fracture although previous studies present discrepant results. We therefore aimed to determine whether the rate of hip fracture was associated with degree of adherence to a Mediterranean diet. We combined two Swedish cohort studies consisting of 37,903 men and 33,403 women (total n = 71,333, mean age 60 years) free of previous cardiovascular disease and cancer who answered a medical and a food-frequency questionnaire in 1997. A modified Mediterranean diet score (mMED; range, 0 to 8 points) was created based on high consumption of fruits and vegetables, legumes and nuts, whole grains, fermented dairy products, fish, and olive/rapeseed oil, moderate intake of alcohol, and low intake of red and processed meat. Incident hip fractures between January 1, 1998, and December 31, 2012, were retrieved from the National Patient Register. Hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for potential confounders were calculated using Cox proportional hazards regression. Differences in age at hip fracture were calculated using multivariable Laplace regression. During follow-up, 3175 hip fractures occurred at a median age of 73.3 years. One unit increase in the mMED was associated with 6% lower hip fracture rate (adjusted HR = 0.94; 95% CI, 0.92 to 0.96) and with a 3-month higher median age at hip fracture (50th percentile difference = 2.8 months; 95% CI, 1.4 to 4.2). Comparing the highest quintile of adherence to the mMED (6 to 8 points) with the lowest (0 to 2 points) conferred an adjusted HR of hip fracture of 0.78 (95% CI, 0.69 to 0.89) and a 12-month higher median age of hip fracture (50th percentile difference = 11.6 months; 95% CI, 4.2 to 19.0). Results were similar in men and women. We conclude that higher adherence to a Mediterranean-like diet is associated with lower risk of future hip fracture. © 2016 American Society for Bone and Mineral Research.

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Section: Introductionmentioning

confidence: 99%

Mediterranean Diet and Hip Fracture in Swedish Men and Women

Byberg

Bellavia

Larsson

et al. 2016

Journal of Bone and Mineral Research

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“…Circulating mir-26a-5p, miR-34a-5p and miR-223-5p were not significantly different between women with or without incident fracture. A difference in the clinical characteristics of our cohort might explain the discrepancy between these results and previous studies [3,25,54,55]. Here, the study was designed to include 434 age-matched women with and without fractures during the 20 years of follow-up and to eliminate the confounding factors that may not be related to the miRNA influence in the two pathologies.…”

Section: Discussionmentioning

confidence: 94%

“…Studies from our group [3,15,49] and others [11–14,50] have previously demonstrated the association of AAC with bone fragility, two processes that share common pathogenetic mechanisms in men and women from various populations, especially in the elderly [51,52]. More specifically, in postmenopausal women, the aggravation in AAC score is linked to the increase in bone resorption in particular when BMD is inversely linked to AAC score [5,12,13].…”

Section: Discussionmentioning

confidence: 99%

“…Although osteoporosis and cardiovascular disease are traditionally viewed as separate disease entities, increased cardiovascular risk is significantly associated with the risk of fragility fracture in hips and vertebrae [1–3]. Both conditions share an increase in prevalence with aging and other risk factors such as menopause, smoking, alcohol consumption and low physical activity [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Selected serum microRNA, abdominal aortic calcification and risk of osteoporotic fracture

et al. 2019

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Context MicroRNA (miRNA) regulate post-transcriptionally the expression of osteogenesis and angiogenesis associated genes and emerge as potential non-invasive biomarkers in vascular and bone diseases. Severe abdominal aortic calcification (AAC) is associated with higher risk of cardiovascular event and of fragility fracture. Objective To identify miRNA linked to the aggravation of AAC and to incident osteoporotic fracture. Design Postmenopausal women (>50 years) with available serum at inclusion and data for each outcome (Kauppila score and incident fracture) were selected from the OFELY prospective cohort. We conducted a case-control study in 434 age-matched women, 50% with incident osteoporotic fracture over 20 years of follow-up and a second study in 183 women to explore AAC over 17 years. Methods Serum expression of three miRNA involved in vascular calcification and bone turnover regulation (miRs-26a-5p,-34a-5p, and -223-5p) was quantified at baseline by TaqMan Advanced miRNA technology and expressed by relative quantification. Outcomes were the association of miRNA levels with (1) incident osteoporotic fractures during 20 years, (2) AAC aggravation during 17 years. Results MiRNA level was not associated with incident fractures (miR-26a-5p: 1.06 vs 0.99, p = 0.07; miR-34a-5p: 1.15 vs 1.26, p = 0.35; miR-223a-5p: 1.01 vs 1.05, p = 0.32). 93 women had an increase in Kauppila score over 17 years while 90 did not. None of the miRNAs was associated with an aggravation in AAC (miR-26a-5p: 1.09 vs 1.10, p = 0.95; miR-34a-5p: 0.78 vs 0.73, p = 0.90; miR-223-5p: 0.97 vs 0.78, p = 0.11). Conclusions Circulating miR-26a-5p, -34a-5p and -223-5p are not significantly associated with incident fracture and AAC aggravation.

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“…Fragility fractures are associated with a high risk of cardiovascular events, and patients with CVD have a higher fracture risk [ 46 47 48 ]. Hip fractures are associated with higher risk of myocardial infarction [ 49 ].…”

Section: Frax ® and Cardiovascular Disease/coronmentioning

confidence: 99%

Association of bone mineral density and trabecular bone score with cardiovascular disease

Chuang

Koo

et al. 2020

Tzu Chi Med J

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Traditionally, osteoporosis and cardiovascular disease (CVD) are considered as separate chronic diseases. Increasing evidence now links osteoporosis with hypertension, abnormal lipid metabolism, atherosclerosis, vascular calcification (VC), and congestive heart failure. VC coexists with bone loss, and aortic calcification is a strong predictor of low bone mineral density (BMD) and fragility fractures. The same holds true for coronary artery calcification (CAC): the lower the BMD, the higher the CAC. Trabecular bone score (TBS) iNsight software can analyze the existing BMD database to obtain the bony microstructure score (TBS). Many TBS-related studies include fracture risk, normal aging, diabetes, potential genes, obesity, and asthma severity prediction. The inverse relationship of TBS to VC may provide insight into bone–vascular interactions in chronic kidney disease. A higher TBS has been associated with moderate, but not high, CAC. One explanation is that bone microstructural remodeling becomes more active during early coronary calcification. Increased risk of 10-year likelihood of hip fracture and major osteoporotic fracture as estimated by the fracture risk assessment tool FRAX ® is significantly and independently associated with more severe CAC scores. Dual-energy X-ray absorptiometry and FRAX ® can be used to predict fracture risk and CAC scores, identifying patients who may benefit from early intervention. This review will discuss the relationship and possible mechanism of BMD, TBS, and FRAX ® with CVD and VC or CAC.

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Vascular calcification and fracture risk

Cited by 14 publications

References 45 publications

Mediterranean Diet and Hip Fracture in Swedish Men and Women

Mediterranean Diet and Hip Fracture in Swedish Men and Women

Selected serum microRNA, abdominal aortic calcification and risk of osteoporotic fracture

Association of bone mineral density and trabecular bone score with cardiovascular disease

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