Vascular cell adhesion molecule-1 (VCAM-1), flow mediated dilatation (FMD) and carotid intima media thickness (IMT) in children with juvenile idiopathic arthritis: Relation to disease activity, functional status and fatigue

Ebraheem, Marwa Fathy; Sallam, Rehab A.; Mohsen, Mona; El-Kady, Basma A.; Elhawary, Galal; Baiomy, Azza

doi:10.1016/j.ejr.2018.05.007

Cited by 7 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Can one measure the cardiovascular risk in JIA patients too? The current study presents the positive association between elevated ESR and cIMT values, which was concordant with the number of previous findings [ 34 , 35 ]. However, other studies have denied the discrepancies in cIMT values in adults diagnosed with JIA in their childhood when compared to their healthy counterparts [ 36 ].…”

Section: Discussionsupporting

confidence: 93%

Why and How Should We Assess the Cardiovascular Risk in Patients with Juvenile Idiopathic Arthritis? A Single-Centre Experience with Carotid Intima-Media Measurements

et al. 2023

View full text Add to dashboard Cite

Background: Children diagnosed with juvenile idiopathic arthritis (JIA) are thought to be more likely to develop cardiovascular disease in adulthood. The factors modulating the cardiovascular risk, involving exposure to secondhand smoking, sedentary lifestyle and abnormal body mass index, might have had a stronger impact during the COVID-19 pandemic. The lack of reliable prognostic markers for a higher probability of cardiovascular events might be solved by carotid intima-media thickness (cIMT) measurement. The paramount goal of the study was to assess its usefulness in JIA patients. Materials and Methods: The results of cIMT measured by a single physician in 45 children diagnosed with JIA were compared to 37 age- and sex-matched healthy counterparts. The analysis also involved anthropometric parameters, laboratory tests, and a survey regarding lifestyle-related factors. Results: Four JIA patients appeared to have cIMT above the 94th percentile. A positive correlation between erythrocytes sedimentation rate (ESR) and right carotid artery percentiles was found. Passive smoking increased the cardiovascular risk regardless of JIA. Doubling the daily screen time during the pandemic led to a significant reduction in children’s physical activity. However, the number of enrolled subjects was not enough to make significant recommendations. Conclusions: cIMT measurements remain an interesting perspective for future cardiovascular screening of children with JIA. It has yet to be determined whether it should be considered in all JIA patients on a reliable basis.

show abstract

Section: Discussionsupporting

confidence: 93%

Why and How Should We Assess the Cardiovascular Risk in Patients with Juvenile Idiopathic Arthritis? A Single-Centre Experience with Carotid Intima-Media Measurements

et al. 2023

View full text Add to dashboard Cite

show abstract

“…In agreement with us, Ebraheem et al [21] and Breda et al [27] reported that carotid IMT was significantly higher among JIA patients as compared to controls with no significant difference among JIA subtypes. Compatible also with our results, there was increased IMT in JIA patient in comparison with controls in the study by Głowińska-Olszewska et al [31].…”

Section: Discussionsupporting

confidence: 89%

“…Similarly, Pietrewicz and Urban [34] found higher IMT in the polyarthritis group compared with oligoarthritis children (0.46 mm vs. 0.43 mm). Also, Ebraheem et al [21] and Evensen et al [33] found no significant difference among JIA subtypes as regards carotid IMT, and this might have been explained by the fact that the study group did not include children with a systemic disease where the intensity of inflammatory lesions is especially high.…”

Section: Discussionmentioning

confidence: 90%

“…In contrast to our finding, Ahmad et al [20] found 42% had oligoarticular type, 34% had polyarticular type, Left femoral intima thickness 0.5 ± 0 0.5 ± 0 0.57 ± 0.05* 16 0.0001 (S) f = ANOVA test; S significant, NS non-significant *LSD was for the systemic onset subtype in all subclinical atherosclerosis parameters except right femoral velocity was for the polyarticular subtype and 24% had systemic type of JIA. Ebraheem et al [21] reported oligoarticular, polyarticular, and systemic types of JIA were 45.45%, 27.27%, and 27.27%, respectively. Also, the prevalence of oligoarticular category was 51.1% in Nordal et al [22] and was 65.2% in Picarelli et al [23] study which were higher than that in our study, and this contrast may be explained by that most of the systemic subtype patients who needed biological therapy were referred to our hospital even from insurance hospitals for a specialized healthcare service We reported a statistically significant decrease in HDL with significant increase in ESR, hs-CRP, total cholesterol, LDL, and triglyceride level in patients than in controls.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Predictors of subclinical cardiovascular affection in Egyptian patients with juvenile idiopathic arthritis subtypes

Alian¹,

esmail²,

Gabr³

et al. 2020

Egypt Rheumatol Rehabil

View full text Add to dashboard Cite

Background To assess the subclinical cardiovascular affection in juvenile idiopathic arthritis (JIA) Egyptian patient subtypes using Doppler ultrasonography (US) for carotid and femoral arteries and detecting their predictors Results Forty percent of the patients were polyarticular type, while 40% were systemic onset and 20% were oligoarticular. There was a statistically significant difference between JIA and controls in all parameters of subclinical atherosclerosis by ultrasonography except right external carotid velocity and (right and left) femoral velocity. There was also a highly significant increase in intima-media thickness (IMT) in systemic onset type of JIA. There was a statistically positive correlation between increased internal carotid velocity (right and left) and high erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), lipid profile, and disease activity. High disease activity and lipid profile were valid predictors of subclinical atherosclerotic cardiovascular affection in JIA. Conclusion Increased cardiovascular risks and subclinical atherosclerosis in patients with JIA especially systemic onset type may be due to higher prevalence of multiple risk factors in these patients. Doppler ultrasonography is a simple, non-invasive technique which can be used to detect subclinical atherosclerosis in JIA. Control of disease activity by treat to target strategy and proper diet control should be applied for every patient with JIA especially those with systemic onset type for future prevention of cardiovascular disease.

show abstract

“…Normal estimates of basal and stimulated ow mediated diameter (FMD) among the studied patients can be attributed to the normal lipid pro le as an important modi er of FMD [23]. However, the lower estimate of the 5 min stimulated FMD in patients with active JIA should alert the thinking about the possible impact of the chronic in ammation alone on the atherogenesis risk [24].…”

Section: Discussionmentioning

confidence: 97%

Juvenile idiopathic arthritis burden on the cardiovascular system: A single centre experience

Shousha,

Ebrahim,

Mostafa

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Adults with adolescent diagnosis of juvenile idiopathic arthritis (JIA), particularly those with the systemic phenotype, were found to have cardiovascular morbidities and earlier fatalities compared to the healthy controls. Objective to outline the possible early cardiovascular changes among patients with JIA. Patients and Methods: In this cross-sectional-controlled study with nested follow up, 57 JIA patients were enrolled and compared to age and sex matched 30 healthy subjects, at the period from September 2021 to September 2022. Patients with active JIA were followed up till remission. Assessment included echocardiography, tissue doppler to measure the carotid and aortic intima-media thickness (CIMT, AIMT), and the brachial artery flow mediated diameter (FMD), and serum endothelium (E)-selectin using ELISA technique. Results Serum levels of E-selectin were higher among JIA patients than in controls (p < 0.001), more increased during activity; whereas E-selectin level did not differ among categories of JIA. The estimated FMD, CIMT and AIMT did not show significant difference between patients and controls, however AIMT showed significant improvement with follow up of active patients and in patients treated with biological therapies. There was valvular affection and significant lower diameter of the left main coronary artery among patients with JIA compared to controls. There were no echocardiographic differences among the 3 categories of JIA, however, decrease in the mitral E/A and right ventricular myocardial performance index was found during follow up. Conclusion soluble E-selectin levels were higher among pediatric patients with JIA, particularly during activity denoting the possibility of early atherogenesis or subclinical cardiovascular disorder. Changes in AIMT during the follow up is another alarming sign. The reported changes were not related to the type of JIA rather than the activity status. Longitudinal cohorts are recommended for more precise evaluation of the cardiovascular burden of JIA.

show abstract

Vascular cell adhesion molecule-1 (VCAM-1), flow mediated dilatation (FMD) and carotid intima media thickness (IMT) in children with juvenile idiopathic arthritis: Relation to disease activity, functional status and fatigue

Cited by 7 publications

References 36 publications

Why and How Should We Assess the Cardiovascular Risk in Patients with Juvenile Idiopathic Arthritis? A Single-Centre Experience with Carotid Intima-Media Measurements

Why and How Should We Assess the Cardiovascular Risk in Patients with Juvenile Idiopathic Arthritis? A Single-Centre Experience with Carotid Intima-Media Measurements

Predictors of subclinical cardiovascular affection in Egyptian patients with juvenile idiopathic arthritis subtypes

Juvenile idiopathic arthritis burden on the cardiovascular system: A single centre experience

Contact Info

Product

Resources

About