Yan et al evaluated the impact of the transradial approach (TRA) on the vasodilatory function of the radial artery when utilized for cardiac catheterization, including coronary angiography and percutaneous coronary intervention (PCI). 1 The right radial artery (RRA) baseline diameter and response to flow-mediated dilation (FMD) and nitroglycerine-mediated dilation (NMD) were measured on day 1 and at 3 months after the TRA procedures. The FMD of the RRA decreased from 11.5% before the procedure to 4.1% (P < .05) on day 1 postprocedure and remained decreased at 0.7% (P < .01) at 3 months after the procedure. The NMD of the RRA decreased from 17.6% before the procedure to 5.4% (P < .05) on day 1 postprocedure and to 6.3% (P < .05) 3 months afterward. As discussed by the authors, 1 catheterization procedures via TRA decrease the radial artery FMD and NMD, resulting in immediate and persistent blunting of vasodilatory function of the radial artery. Three months later, the FMD and NMD were still decreased compared to before the procedure. The TRA impairs not only endothelial-dependent vasodilation but also endothelialindependent (vascular smooth muscle dependent) vasodilation, indicated by the decrease in FMD and NMD, respectively. Therefore, the authors 1 concluded that patients catheterized by TRA should have radial artery structure and function evaluated before any plan to use the artery as a coronary artery bypass graft (CABG).Yan et al, 2 in an earlier study, showed that coronary procedures via TRA can lead to increased RRA intima-media thickness (IMT) and a decrease in RRA diameter early after the procedure. A subsequent significant recovery in IMT occurred but there was no return to baseline. 2 The mean IMT of the RRA increased from 0.25 + 0.12 mm before the procedure to 0.69 + 0.31 mm 1 day following the procedure (P < .01) and to 0.38 + 0.17 mm 1 month later (P < .05). The decrease in mean RRA diameter followed a similar pattern. There was no RRA stenosis or occlusion before the TRA procedures. However, the incidence of RRA stenosis was 15.7% 1 day following the procedure and 7.6% 1 month later (P < .05 compared to 1 day following the procedures). The incidence of RRA occlusion was 0%, 2.8%, and 1.7%, respectively. 2 Paraskevas et al commented in a subsequent editorial that the TRA is not always a benign procedure and can be associated with short-and long-term effects that may compromise the RRA luminal wall. 3 Furthermore, they emphasized that repetitive RRA catheterizations may exacerbate the procedural problems resulting in failure to recover from the injury. Paraskevas et al even suggested the potential importance of trials involving routine preprocedural use of statins, which might suppress vascular hyperplasia, improve arterial IMT, reduce high-sensitivity C-reactive protein levels, and maximally improve the function of the endothelium. 3 The TRA has also been evaluated in patients with previous CABG surgery. Han et al evaluated 124 consecutive patients with a history of CABG surgery who underwent graft...