Vascular Complications of Q-fever Infections

Wegdam-Blans, Marjolijn C A; Vainas, Tryfon; Sambeek, M.R. van; Cuypers, Philippe W.M.; Tjhie, H.T.; Straten, Albert H.M. van; Teijink, Joep A.W.

doi:10.1016/j.ejvs.2011.04.013

Cited by 71 publications

(84 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of the disease is low and may vary between 0.15 and 0.35/100,000 population per year. 1 Although most of the acute form of the disease is asymptomatic, chronic Q fever involve cardiovascular manifestations such as endocarditis in 60% to 70% of cases and vascular infections such as aneurysms or vascular graft infections in 7%. 2 Up to 11% of patients with acute Q fever evolve to a chronic form of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Thoracic and abdominal aortic aneurysms were mostly seen, followed by peripheral aneurysms and graft infections. 1 Most patients were treated by surgical resection with a mortality rate of 24%, while those treated conservatively by antibiotics alone had a higher mortality rate (70%). 1 Whether this high mortality rate is attributed to poor patient conditions or to high disease aggressiveness remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…1 Most patients were treated by surgical resection with a mortality rate of 24%, while those treated conservatively by antibiotics alone had a higher mortality rate (70%). 1 Whether this high mortality rate is attributed to poor patient conditions or to high disease aggressiveness remains unclear. In our case, an open surgical repair was not an option due to the frailty of the patient.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Embolization of a Large Rapidly Growing Aortic Pseudo-Aneurysm Not Amenable to Open or Endovascular Repair

Gemayel

Mootoosamy

Murith

et al. 2016

Annals of Vascular Surgery

View full text Add to dashboard Cite

Background: To report the case of a rapidly growing aortic false aneurysm because of Q fever infection that was managed by embolization. Case report: An 80-year-old man was admitted to our unit for an aortic false aneurysm from a chronic Q fever infection. During his stay, the aneurysm showed rapid progression necessitating urgent treatment. The patient was unfit for surgical repair; moreover, the location of the aneurysm at the level of the superior mesenteric artery prohibited the use of an endovascular graft. He was managed by coiling of the aneurysmal cavity with multiple detachable coils after positioning of a bare aortic stent to lock the coils and prevent their migration into the aortic lumen. The false aneurysm was successfully thrombosed with no complications. The patient was then put on doxycycline and hydroxychloroquine to target Coxiella burnetii. Conclusions: Aortic false aneurysm coiling is feasible in cases where an endograft is not possible or an open repair is contraindicated. The use of a bare metal stent may help as a barrier to prevent the coils from migrating into the aneurysm and thus avoiding embolization into the systemic circulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Embolization of a Large Rapidly Growing Aortic Pseudo-Aneurysm Not Amenable to Open or Endovascular Repair

Gemayel

Mootoosamy

Murith

et al. 2016

Annals of Vascular Surgery

View full text Add to dashboard Cite

show abstract

“…Q fever has reportedly been associated with abdominal aortic aneurysm, aortoenteric fistula, lower limb fistula, vascular graft infection, vertebral body erosions, CNS infection, fever of unknown origin, and possible pancreatitis [3,4,[7][8][9][10]. Mass lesions are one of the rarest presentations of Q fever.…”

Section: Discussionmentioning

confidence: 99%

“…Common manifestations of persistent localized Q fever infection include endocarditis, infectious thoracoabdominal aortic aneurysm, vascular graft infection, bone lesions, pulmonary infection, and granulomatous hepatitis. Encephalitis, pericarditis, and myocarditis have also been reported [3,4]. In addition, there are rare reports of Coxiella burnetii infection presenting as mass lesions in the lung, mimicking malignant tumors radiographically [5,6].…”

Section: Introductionmentioning

confidence: 99%

321 Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass

Nowroozizadeh

Mehmandari

Gallegos

et al. 2018

American Journal of Clinical Pathology

View full text Add to dashboard Cite

Background. Q fever is an infection caused by Coxiella burnetii, an intracellular organism. Acute infection is most often a benign and asymptomatic process; however, some individuals may go on to develop subacute and persistent localized symptomatic Q fever. As such, the clinical and histopathologic findings of Q fever are widely variable and may be missed if clinical suspicion is not high. Case Presentation. Herein we report the first case of C. burnetii infection presenting as an isolated retroperitoneal mass. A 61-year-old male underwent axillary-bifemoral bypass surgery. His postoperative course was complicated by the discovery of a large retroperitoneal mass. Conclusion. Clinical and histopathologic findings of Coxiella burnetii infection are variable and can be deceiving. These are often nonspecific, especially in its persistent localized infectious stages.

show abstract

Targeted screening as a tool for the early detection of chronic Q fever patients after a large outbreak

Wegdam-Blans

Stokmans

Tjhie

et al. 2012

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

In the aftermath of the Dutch Q fever outbreak, an increasing number of patients are being diagnosed with chronic Q fever. Most of these patients are unaware of being infected with Coxiella burnetii, the causative agent of Q fever. To find patients in an earlier, asymptomatic stage, a targeted screening strategy (TSS) for patients with risk factors for chronic Q fever was started in the southeast region of Noord-Brabant. In total, 763 patients were tested using an IgG phase II indirect fluorescent antibody test (IFAT), of which 52 (7 %) patients tested positive. Ten of these 52 patients displayed a chronic Q fever serological profile. All of these 10 patients had a heart valve(s) or (endo-)vascular prosthesis. All except one were asymptomatic. Suggestive signs for chronic infections on positron emission tomography-computed tomography (PET-CT) were demonstrated in 5 (50 %) of these patients. Forty-two out of the 52 patients with a positive screening test showed a past Q fever serological profile. After a year of follow-up (every 3 months), none of these patients showed elevation of antibody titres and no new chronic Q fever patients were found in this group. A targeted screening programme is a useful instrument for detecting patients at risk of developing chronic Q fever.

show abstract

Vascular Complications of Q-fever Infections

Abstract: Aneurysms associated with Q-fever infections tend to be complicated, requiring challenging surgical corrections, and long-term antibiotic treatment. Major complications and mortality rates are significant, especially in conservatively treated patients.

Cited by 71 publications

References 30 publications

Embolization of a Large Rapidly Growing Aortic Pseudo-Aneurysm Not Amenable to Open or Endovascular Repair

Embolization of a Large Rapidly Growing Aortic Pseudo-Aneurysm Not Amenable to Open or Endovascular Repair

321 Q Fever Presented as a Large Retroperitoneal Pseudotumoral Mass

Targeted screening as a tool for the early detection of chronic Q fever patients after a large outbreak

Contact Info

Product

Resources

About