Vascular disease, including vascular dementia.

Nation, Daniel A.

doi:10.1037/0000307-020

Cited by 1 publication

(1 citation statement)

References 78 publications

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“…Vascular dementia is a neurodegenerative condition resulting from brain damage caused by disruptions in blood flow to the brain, leading to significant impacts on cognitive and psychomotor functions [ 1 , 2 , 3 ]. It represents the second most common type of dementia after Alzheimer’s disease (AD), affecting approximately 46.8 million individuals worldwide and contributing to at least 20–25% of total dementia cases [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Gangemi,

Fabio,

Suriano

et al. 2024

Biomedicines

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Vascular dementia, the second most common type of dementia, currently lacks a definitive cure. In the pursuit of therapies aimed at slowing its progression and alleviating symptoms, transcranial direct current stimulation (tDCS) emerges as a promising approach, characterized by its non-invasive nature and the ability to promote brain plasticity. In this study, the primary objective was to investigate the effects of a two-week cycle of tDCS on the dorsolateral prefrontal cortex (DLPFC) and neurophysiological functioning in thirty patients diagnosed with vascular dementia. Each participant was assigned to one of two groups: the experimental group, which received anodal tDCS to stimulate DPCFL, and the control group, which received sham tDCS. Neurophysiological functions were assessed before and after tDCS using P300 event-related potentials (ERPs), while neuropsychological function was evaluated through a Mini-Mental State Examination (MMSE). The results showed a reduction in P300 latency, indicating a faster cognitive process; an increase in P300 amplitude, suggesting a stronger neural response to cognitive stimuli; and a significant improvement in MMSE scores compared to the control group, indicating an overall enhancement in cognitive functions. These findings suggest that tDCS could represent a promising therapeutic option for improving both neurophysiological and cognitive aspects in patients with vascular dementia.

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