Vascular dysfunction in multiple sclerosis: Scoping review of current evidence for informing future research directions

DuBose, Noah G.; DeJonge, Sydney R.; Jeng, Brenda; Motl, Robert W.

doi:10.1016/j.msard.2023.104936

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…Susceptible individuals, genetically predisposed, can encounter environmental triggers like viral infections, precipitating the activation of autoreactive T cells. These T cells traverse the blood-brain barrier and infiltrate the CNS, where they misconstrue myelin proteins as antigens, inciting an immune reaction [66]. This immune response activates immune cells, including macrophages and microglia, which discharge pro-inflammatory cytokines, chemokines, and other agents fostering inflammation and detriment to myelin and nerve cells.…”

Section: Multiple Sclerosismentioning

confidence: 99%

“…This immune response activates immune cells, including macrophages and microglia, which discharge pro-inflammatory cytokines, chemokines, and other agents fostering inflammation and detriment to myelin and nerve cells. This inflammatory cascade can give rise to demyelinated plaques and axonal loss, the elongated projections of nerve cells accountable for transmitting electrical impulses [66,67].…”

Section: Multiple Sclerosismentioning

confidence: 99%

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Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease

Osuna-Ramos,

Camberos-Barraza,

Torres-Mondragón

et al. 2023

IJMS

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The intricate mechanisms governing brain health and function have long been subjects of extensive investigation. Recent research has shed light on two pivotal systems, the glymphatic system and the endocannabinoid system, and their profound role within the central nervous system. The glymphatic system is a recently discovered waste clearance system within the brain that facilitates the efficient removal of toxic waste products and metabolites from the central nervous system. It relies on the unique properties of the brain’s extracellular space and is primarily driven by cerebrospinal fluid and glial cells. Conversely, the endocannabinoid system, a multifaceted signaling network, is intricately involved in diverse physiological processes and has been associated with modulating synaptic plasticity, nociception, affective states, appetite regulation, and immune responses. This scientific review delves into the intricate interconnections between these two systems, exploring their combined influence on brain health and disease. By elucidating the synergistic effects of glymphatic function and endocannabinoid signaling, this review aims to deepen our understanding of their implications for neurological disorders, immune responses, and cognitive well-being.

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Section: Multiple Sclerosismentioning

confidence: 99%

Section: Multiple Sclerosismentioning

confidence: 99%

Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease

Osuna-Ramos,

Camberos-Barraza,

Torres-Mondragón

et al. 2023

IJMS

View full text Add to dashboard Cite

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Advancements and Challenges in Exercise Training for Multiple Sclerosis: Comprehensive Review and Future Directions for Randomized Controlled Trials

Motl,

Pilutti

2024

Neurol Ther

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Exercise training represents a health behavior for the treatment and management of the multi-faceted manifestations of multiple sclerosis (MS). This paper provides a comprehensive overview of evidence from randomized controlled trials (RCTs) regarding benefits, safety, participation, and guidelines for exercise training in MS, based on systematic reviews and meta-analyses. The paper then provides our opinions based on extensive experience regarding challenges for improving and expanding future RCTs that will advance our understanding of exercise training in MS. The comprehensive review of evidence from RCTs indicates that exercise training yields substantial improvements in aerobic and muscle fitness, mobility, fatigue and depression, quality of life, and participation outcomes. There is a non-significant increase in the risk of adverse events or serious adverse events with exercise training compared with control conditions or healthy populations. Rates of adherence and compliance with exercise training (i.e., participation) approximate 80% and 70%, respectively. The current prescriptive guidelines suggest 2–3 days per week of aerobic and resistance exercise training as the minimal dose for safely benefiting from exercise training in MS. We propose 10 important topics as avenues for expanding the body of research and improving its scope for evidence-based practice in MS. Overall, the research on exercise training in MS is strong, but it can get stronger. The expansion and advancement of evidence are critical for moving exercise training into the clinical armamentarium of MS disease treatment and management.

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Vascular function in multiple sclerosis: Systematic review with meta-analysis

Zheng,

DuBose,

DeJonge

et al. 2024

Multiple Sclerosis and Related Disorders

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Vascular dysfunction in multiple sclerosis: Scoping review of current evidence for informing future research directions

Cited by 4 publications

References 51 publications

Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease

Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease

Advancements and Challenges in Exercise Training for Multiple Sclerosis: Comprehensive Review and Future Directions for Randomized Controlled Trials

Vascular function in multiple sclerosis: Systematic review with meta-analysis

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