Vascular effects of photodynamic and pulsed dye laser therapy protocols

Channual, Jennifer; Choi, Bernard; Osann, Kathryn; Pattanachinda, Daniel; Lotfi, Justin; Kelly, Kristen M.

doi:10.1002/lsm.20673

Cited by 37 publications

(32 citation statements)

References 39 publications

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“…In all cases, both vascular perfusion and velocity of blood flow increased immediately after PDT and returned to baseline values within several hours to months post-PDT 202,203,207,208. These examples used superficial tissue samples including skin cancers202,203 and dorsal skin-fold chambers 207,208. Angiography has long been used to monitor choroidal neovascularization from age-related macular degeneration 164–166,209.…”

Section: Imaging For Planning Assessment and Monitoring Of Photomentioning

confidence: 99%

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

et al. 2010

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Section: Imaging For Planning Assessment and Monitoring Of Photomentioning

confidence: 99%

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

et al. 2010

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“…The U.S. Food and Drug Administration approved by BPD for the treatment of wet age-related macular degeneration, skin carcinoma, and brain tumors. With a series of preclinical studies [88–91], we demonstrated promising results with the combination of BPD-mediated PDT combined with PDL irradiation. We then initiated clinical translation of the protocol in a Phase I FDA approved trial of PDT+PDL for treatment of PWS [92] and demonstrated that PDT+PDL is more effective for selective removal of cutaneous microvasculature, as compared to PDL alone.…”

Section: Development Of New Treatment Approachesmentioning

confidence: 99%

The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities

Choi

Tan

Jia

et al. 2016

IEEE J. Select. Topics Quantum Electron.

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Here, we review our current knowledge on the etiology and treatment of port-wine stain (PWS) birthmarks. Current treatment options have significant limitations in terms of efficacy. With the combination of 1) a suitable preclinical microvascular model, 2) laser speckle imaging (LSI) to evaluate blood-flow dynamics, and 3) a longitudinal experimental design, rapid preclinical assessment of new phototherapies can be translated from the lab to the clinic. The combination of photodynamic therapy (PDT) and pulsed-dye laser (PDL) irradiation achieves a synergistic effect that reduces the required radiant exposures of the individual phototherapies to achieve persistent vascular shutdown. PDL combined with anti-angiogenic agents is a promising strategy to achieve persistent vascular shutdown by preventing reformation and reperfusion of photocoagulated blood vessels. Integration of LSI into the clinical workflow may lead to surgical image guidance that maximizes acute photocoagulation, is expected to improve PWS therapeutic outcome. Continued integration of noninvasive optical imaging technologies and biochemical analysis collectively are expected to lead to more robust treatment strategies.

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“…Additional antivascular approaches include photodynamic therapy (PDT)18192021, embolotherapy22232425, antivascular ultrasound therapy (AVUT)262728, and photothermolysis29. These approaches have been developed to shut down or destroy existing blood vessels.…”

mentioning

confidence: 99%

High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation

Zhang

Mordovanakis

et al. 2017

Sci Rep

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Antivascular therapy represents a proven strategy to treat angiogenesis. By applying synchronized ultrasound bursts and nanosecond laser irradiation, we developed a novel, selective, non-invasive, localized antivascular method, termed photo-mediated ultrasound therapy (PUT). PUT takes advantage of the high native optical contrast among biological tissues and can treat microvessels without causing collateral damage to the surrounding tissue. In a chicken yolk sac membrane model, under the same ultrasound parameters (1 MHz at 0.45 MPa and 10 Hz with 10% duty cycle), PUT with 4 mJ/cm2 and 6 mJ/cm2 laser fluence induced 51% (p = 0.001) and 37% (p = 0.018) vessel diameter reductions respectively. With 8 mJ/cm2 laser fluence, PUT would yield vessel disruption (90%, p < 0.01). Selectivity of PUT was demonstrated by utilizing laser wavelengths at 578 nm or 650 nm, where PUT selectively shrank veins or occluded arteries. In a rabbit ear model, PUT induced a 68.5% reduction in blood perfusion after 7 days (p < 0.001) without damaging the surrounding cells. In vitro experiments in human blood suggested that cavitation may play a role in PUT. In conclusion, PUT holds significant promise as a novel non-invasive antivascular method with the capability to precisely target blood vessels.

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Vascular effects of photodynamic and pulsed dye laser therapy protocols

Cited by 37 publications

References 39 publications

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities

High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation

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