2002
DOI: 10.1016/s1053-2498(02)00457-6
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Vascular endothelial cell apoptosis induced by anti-donor non-MHC antibodies: a possible injury pathway contributing to chronic allograft rejection

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Cited by 41 publications
(23 citation statements)
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“…Studies in adults suggest that graft coronary artery disease and chronic rejection could be a significant factor here. [27][28][29] However, a previous study at our own institution that used intravascular ultrasound in a cohort of 137 patients showed only a 10% prevalence of coronary artery disease. 30 In 28 of our 30 patients in this series, a recent coronary angiogram had confirmed normal findings.…”
Section: Discussionmentioning
confidence: 94%
“…Studies in adults suggest that graft coronary artery disease and chronic rejection could be a significant factor here. [27][28][29] However, a previous study at our own institution that used intravascular ultrasound in a cohort of 137 patients showed only a 10% prevalence of coronary artery disease. 30 In 28 of our 30 patients in this series, a recent coronary angiogram had confirmed normal findings.…”
Section: Discussionmentioning
confidence: 94%
“…Positive C4d staining without concurrently detectable serum alloantibodies (which occurs in about 10% of human biopsies) might be due to non-HLA alloantibodies (47)(48)(49) ) or adsorption of antibodies by the graft. This study supports the later possibility because most of the alloantibody-negative, C4d-positive animals became alloantibody positive on subsequent testing or lost the C4d staining.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, this method has been particularly informative inrat and mouse models of chronic rejection. [39][40][41][42] Measurement of donor-specific allo-antibodies in patients awaiting transplantation has proven very useful in estimating the degree to which the recipient is sensitized to a given allograft. Analyzing de-novo donor specific antibodies in transplant patients is becoming more common.…”
Section: Prediction: the Direction For New Diagnostic Methodologiesmentioning
confidence: 99%