Vascular Endothelial Growth Factor 05 Provide Additional Values to C-Reactive Protein and Anti-myeloperoxidase Titer as a Parameter for Evaluating Disease Activity in Anti-myeloperoxidase Associated Vasculitis

Peng, Ching-Hsiu; Lin, Che-Kai; Yang, Chih‐Wei; Shueh, S; Huang, Chiu‐Ching

doi:10.1081/jdi-120026042

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…There has been several reports showing the clinical value of VEGF in monitoring disease activity in vasculitis including MPA. [24][25][26] Our result is compatible with previous reports and we propose that serum VEGF might become one of the serum markers that reflect disease activity of MPA. We also showed that serum VEGF levels in MPA patients were significantly higher than those in respiratory tract infection and urinary tract infection.…”

Section: Discussionsupporting

confidence: 92%

Increased serum vascular endothelial growth factor levels in microscopic poly angiitis with pulmonary involvement

Iwakawa

Matsuyama

Kubota

et al. 2006

Respiratory Medicine

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Microscopic polyangiitis (MPA) is a systemic necrotizing vasculitis that affects small vessels, resulting in a wide spectrum of organ involvement including the lungs. However, there are little serological markers that predict its prognosis or severity of pulmonary involvement. Vascular endothelial growth factor (VEGF) is an angiogenic mediator, which has been reported to be elevated in systemic vasculitis. In this study, we measured serum VEGF levels in 22 MPA patients with pulmonary involvement. We also investigated VEGF expression in pulmonary cells using flow cytometry analysis. We found that serum VEGF levels in MPA patients were significantly higher than those in respiratory or urinary tract infection. The serum VEGF levels decreased in parallel with the improvement of MPA symptoms. The serum VEGF levels in MPA patients who died within 5 years were significantly higher than those who survived more than 5 years. The sensitivity of VEGF levels to distinguish MPA patient with poor prognosis from those with good prognosis was 90.9%, and specificity was 81.8% (cutoff value = 802.5 pg/ml). The serum VEGF levels showed significant positive correlation with the composite physiological index, which indicates the severity of pulmonary lesion. In flow cytometry analysis, CD11b positive bronchoalveolar lavage fluid cells expressed VEGF. Immunohistochemically, alveolar macrophages, tissue infiltrating inflammatory cells and alveolar epithelial cells stained positive for VEGF. Measurement of serum VEGF levels in MPA might become one of the markers for prognosis and the severity of pulmonary involvement in MPA. VEGF might contribute to the development of pulmonary lesion of MPA.

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Section: Discussionsupporting

confidence: 92%

Increased serum vascular endothelial growth factor levels in microscopic poly angiitis with pulmonary involvement

Iwakawa

Matsuyama

Kubota

et al. 2006

Respiratory Medicine

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“…In addition to the role of EGFR signaling in the AAV pathogenesis, our bioinformatic analysis also highlighted the inclusion of vascular endothelial growth factor (VEGF) signalization among the biological pathways regulated by the targets of miRNAs with elevated levels in uEVs in patients (Figure 3). This association was mentioned only in one case report, where the correlation between serum VEGF levels with C-reactive protein and anti-MPO titer was clearly demonstrated [44].…”

Section: Discussionmentioning

confidence: 99%

Analysis of microRNAs in Small Urinary Extracellular Vesicles and Their Potential Roles in Pathogenesis of Renal ANCA-Associated Vasculitis

Frýdlová

Svobodová

Satrapová

et al. 2022

IJMS

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Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) represents an autoimmunity disease characterized by high mortality. For successful treatment, the detailed knowledge of its complex pathogenesis and the set of biomarkers for differential diagnostics are desired. Analysis of molecular content of small urinary extracellular vesicles (uEV) offers the possibility to find markers in the form of microRNAs (miRNAs) and study the pathways involved in pathogenesis. We used next-generation sequencing in the first preliminary study to detect the miRNAs with altered expression in uEVs of patients with AAV in comparison with age-matched controls. We confirmed the results using single-target quantitative polymerase chain reaction tests on different sets of samples and found five miRNAs (miR-30a-5p, miR-31-3p, miR-99a-5p, miR-106b-5p, miR-182-5p) with highly elevated levels in uEVs of patients. We performed the comparison of their targets with the differentially expressed proteins in uEVs of patients included in the first phase. We realized that upregulated miRNAs and proteins in uEVs in AAV patients target different biological pathways. The only overlap was detected in pathways regulating the actin cytoskeleton assembly and thus potentially affecting the glomerular functions. The associations of upregulated miRNAs with pathways that were neglected as components of complex AAV pathogenesis, e.g., the epidermal growth factor receptor signaling pathway, were found.

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“…32 Studies have shown the clinical value of VEGF-A in monitoring disease activity in vasculitis, including MPA. 19,33 Shulman et al. 34 reported that VEGF-A expression is altered in many glomerular diseases.…”

Section: Discussionmentioning

confidence: 99%

“…18 Correlations of VEGF-A concentrations with serum CRP (sCRP) and anti-myeloperoxidase (MPO) titres have been demonstrated; these suggest that VEGF-A is a potential marker for monitoring disease activity in anti-MPO-associated vasculitis. 19 However, the relationship between VEGF-A and VEGF-A 165 b concentrations and patient prognosis in longitudinal samples is unknown.…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor (VEGF)-A and VEGF-A₁₆₅b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study

et al. 2020

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Background: Effective prognostic markers are needed for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This study evaluated the clinical associations of serum vascular endothelial growth factor-A (sVEGF-A) and sVEGF-A165b (an anti-angiogenic isoform of VEGF-A) levels with time to remission of AAV in a nationwide Japanese prospective follow-up cohort. Methods: We collected samples from patients with AAV who were enrolled in the nationwide Japanese cohort study (RemIT-JAV-RPGN). We measured sVEGF-A and sVEGF-A165b levels using enzyme-linked immunosorbent assays in 57 serum samples collected 6 months before and after initiation of AAV treatment. Patients were classified based on AAV disease subtypes: microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Results: Results revealed significant reductions in sVEGF-A and sVEGF-A165b levels in patients with MPA and EGPA, respectively. However, despite the comparable levels of sVEGF-A and sVEGF-A165b during the 6 months of treatment in GPA patients, correlation analysis revealed that the differences in log2-transformed levels of sVEGF-A and sVEGF-A165b were negatively correlated with time to remission in GPA patients. Conclusion: These results suggest that sVEGF-A and sVEGF-A165b can serve as potential markers of time to remission in patients with GPA.

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Vascular Endothelial Growth Factor 05 Provide Additional Values to C-Reactive Protein and Anti-myeloperoxidase Titer as a Parameter for Evaluating Disease Activity in Anti-myeloperoxidase Associated Vasculitis

Cited by 4 publications

References 19 publications

Increased serum vascular endothelial growth factor levels in microscopic poly angiitis with pulmonary involvement

Increased serum vascular endothelial growth factor levels in microscopic poly angiitis with pulmonary involvement

Analysis of microRNAs in Small Urinary Extracellular Vesicles and Their Potential Roles in Pathogenesis of Renal ANCA-Associated Vasculitis

Vascular endothelial growth factor (VEGF)-A and VEGF-A₁₆₅b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study

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Vascular Endothelial Growth Factor 05 Provide Additional Values to C-Reactive Protein and Anti-myeloperoxidase Titer as a Parameter for Evaluating Disease Activity in Anti-myeloperoxidase Associated Vasculitis

Cited by 4 publications

References 19 publications

Increased serum vascular endothelial growth factor levels in microscopic poly angiitis with pulmonary involvement

Increased serum vascular endothelial growth factor levels in microscopic poly angiitis with pulmonary involvement

Analysis of microRNAs in Small Urinary Extracellular Vesicles and Their Potential Roles in Pathogenesis of Renal ANCA-Associated Vasculitis

Vascular endothelial growth factor (VEGF)-A and VEGF-A165b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study

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Vascular endothelial growth factor (VEGF)-A and VEGF-A₁₆₅b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study