Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis

Abstract

ABSTRACT.This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case-control studies were included in this meta-analysis. The associations between the VEGF gene 405G/C and -2578C/A polymorphisms and breast cancer risk were estimated by pooled ORs and 95%CIs using fixed-or random-effect models. Meta-analysis results showed no significant association between the 405G/C polymorphism and breast cancer risk 8909-8918 (2015) model: OR = 1.03, 95%CI = 0.94-1.13). Similar results were observed in the subgroup analyses on ethnicity, sample size, and Hardy-Weinberg equilibrium. These findings suggested a lack of association between the VEGF gene 405G/C and -2578C/A polymorphisms and breast cancer susceptibility.

Association between Vascular Endothelial Growth Factor Gene Polymorphisms with Breast Cancer Risk in an Iranian Population

“…[30][31][32] The results of meta-analysis indicated that rs2010963 (+405CG) and rs699947 (-2578CA) variants of VEGF were not associated with BC susceptibility. 33,34 The results of a meta-analysis performed by Li and Ju 35 indicated that the functionally important +936 C/T polymorphism of VEGF is not associated with BC risk. The results of meta-analysis indicated that VEGF +936CC genotype and +936C allele increased the risk of BC and tumor growth, especially in Asians.…”

Association of ABCB1 and VEGFA gene polymorphisms with breast cancer susceptibility and prognosis

“…(OR = 0.99, 95%CI: 0.89-1.10); recessive model: (OR: 1.03, 95%CI: 0.94-1.13); dominant model: (OR: 1.00, 95%CI: 0.90-1.10) (27). No confounding effect of ethnicity was shown, since the stratified analysis either in Asians or Caucasians showed no significant association (27). Two later studies have shown an increased risk of BC in patients carrying the A-allele of VEGFA 2578C/A gene polymorphism (28,29).…”

“…A meta-analysis encompassing 7 studies (4572 cases/4652 controls) did not find association between the VEGFA 2578C/A polymorphism and susceptibility to BC in any of the genetic models tested either in the analysis by ethnicity (Asians and Caucasians) (27). Two studies were published after this meta-analysis.…”