Vascular Endothelial Growth Factor A serum levels and common gene polymorphisms in generalized periodontitis affected patients

Kriauciunas, Albertas; Zekonis, Gediminas; Gedvilaite, Greta; Duseikaitė, Monika; Pileckaitė, Enrika; Pacauskiene, Ingrida; Liutkeviciene, Rasa

doi:10.1080/00016357.2023.2260000

Acta Odontologica Scandinavica

2023

DOI: 10.1080/00016357.2023.2260000

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Vascular Endothelial Growth Factor A serum levels and common gene polymorphisms in generalized periodontitis affected patients

Albertas Kriauciunas,

Gediminas Zekonis,

Greta Gedvilaite

et al.

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2024

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Evaluation of salivary placental growth factor in Health and Periodontitis

Alshamsi,

Koippallil Gopalakrishnan,

Rahman

et al. 2024

BMC Oral Health

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Background Various immune mediators have a role in the progression of periodontitis. Placental Growth Factor (PLGF) is important during pregnancy and also is involved in the pathology of several diseases. Hence, this study aimed to evaluate salivary PLGF in health and periodontitis that seemingly has not been reported earlier. Methods Fifty participants were grouped as healthy and periodontitis patients. Clinical history, periodontal parameters [Plaque Index (PI), Gingival Index (GI), probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BoP)] were recorded; saliva was collected and PLGF was estimated using a commercially available ELISA kit. The data were statistically analyzed using Shapiro-Wilk’s test, Kruskal-Wallis test, Dunn’s post hoc test with Bonferroni correction, and Spearman’s rank-order correlation coefficient. The significance level was set at p ≤ 0.05 for all tests. Results Salivary PLGF levels comparison between the two groups showed no significant difference between both groups. Quantitatively, females had higher salivary PLGF levels than males. No significant association was observed between salivary PLGF levels and the severity of periodontitis. The periodontitis group showed statistically significant correlations between salivary PLGF levels, BoP(p = 0.005) and PPD(p = 0.005), and significant correlations of PLGF with PPD (p = 0.035) for both groups. Conclusions PLGF can be detected and measured in the saliva of healthy individuals and periodontitis patients. However, the role of PLGF in periodontal pathology needs to be further confirmed based on their salivary levels.

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Evaluation of salivary placental growth factor in Health and Periodontitis

Alshamsi,

Koippallil Gopalakrishnan,

Rahman

et al. 2024

BMC Oral Health

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show abstract

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Vascular Endothelial Growth Factor A serum levels and common gene polymorphisms in generalized periodontitis affected patients

Cited by 1 publication

References 44 publications

Evaluation of salivary placental growth factor in Health and Periodontitis

Evaluation of salivary placental growth factor in Health and Periodontitis

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