Vascular endothelial growth factor-A and transforming growth factor-β1 expression in postmenopausal osteoporosis

Omar, Sahar M.M.; Sweed, Hala S.; Abulsaad, Khaled A.; Sharara, Sherine Mohamed

doi:10.1097/01.ehx.0000455271.60795.a7

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…Group II of our study revealed significant decrease of PAS positive reaction in fundic mucosal cells, consistent with some researches [3,7,33,34] , whereas ethanol-induced ulcer was associated with decrease of PAS positive reaction in fundic mucosal cells as result of ethanol damaging effect on the mucus cells or excessive oxidative stress. Moreover, there was a significant decrease of expression VEGF immunostaining in gastric mucosa, similar to some previous histopathological studies [35,36] .…”

Section: Discussionsupporting

confidence: 90%

Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

El-Azab

Mansy

El-Mahalaway

et al. 2018

Egyptian Journal of Histology

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Introduction: Gastric ulcers are the most prevalent gastrointestinal disorders. Pomegranate fruits have many beneficial therapeutic effects. Bone marrow mesenchymal stem cells (BMSCs) are a novel approach with promising therapeutic potential for curing human diseases. Aim of the work: To evaluate the effect of pomegranate and BMSCs on experimentally induced gastric ulcer in adult male rats. Materials and Methods: Sixty adult male rats were divided into four groups. Group I kept as the control group. Group II (Gastric ulcer), rats received 100% ethanol orally by gastric tube. Group (III) subdivided into 3 subgroups. Subgroup IIIa included rats with gastric ulcer that treated with pomegranate only. Subgroup IIIb, rats with gastric ulcer treated with BMSCs alone. Subgroup IIIc; gastric ulcer rats treated with a combination of pomegranate and BMSCs. Group IV included the untreated gastric ulcer rats. Fundus of stomach specimens were prepared and examined using histological and immunohistochemical techniques. Results: Groups II and IV showed various changes as deep erosion, marked damage of most of the cells. The presence of the inflammatory cells in gastric mucosa were supported by a significant increase of tumor necrosis factor α (TNF-α) expression and collagen fibers depositions (P<0.01). A significant decrease of Periodic Acid Schiff (PAS) positive reaction and vascular endothelial growth factor (VEGF) expression was observed (P<0.01). Subgroup IIIa showed attenuation of some histological changes, while subgroups IIIb and IIIc revealed more improvement of the histological and immunohistochemical changes described before. Conclusion: BMSCs can ameliorate experimentally-induced gastric injury in rats and protect the gastric tissue. Addition of pomegranate to BMSCs can lead to better results.

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