Vascular endothelial growth factor‐A gene polymorphism is associated with congenital renal lesions in children with urinary tract infections

Bimpaki, Eirini I.; Bitsori, María; Choulaki, Christiana; Galanakis, Emmanouil

doi:10.1111/apa.13897

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…One of the target genes of HIF-1 is VEGF. Indeed, VEGF is currently considered to be the most important angiogenic factor which promotes the migration and proliferation of endothelial cells and enhances their permeability and angiogenesis [13].…”

Section: Discussionmentioning

confidence: 99%

Differential expressions of TGF-β1, HIF-1, VEGF, α-SMA and E-cadherin in renal tissues of a neonatal rat model of hydronephrosis

Wang¹,

He²,

Zhu³

et al. 2021

Trop. J. Pharm Res

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Purpose: To investigate the differential expressions of transforming growth factor-β1 (TGF-β1), hypoxia inductive factor-1 (HIF-1), vascular endothelial growth factor (VEGF), α-smooth muscle protein (α-SMA) and E-cadherin in renal tissues of neonatal rat model of hydronephrosis.Methods: The neonatal rats (90) were randomly divided into sham group and model group. The rats in the model group were further divided into two subgroups: week 1 and week 12 after relief of obstruction, with 30 rats in each group. Six rats were taken from each group for the determination of renal histopathological changes. Levels of TGF-β1, HIF-1, VEGF, α-SMA and E-cadherin in renal tissues were compared for different pathological grades and at different time points of obstruction relief.Results: With increase in Elder grade, the concentrations of TGF-β1, HIF-1, VEGF and α-SMA in renal tissues of hydronephrosis neonatal rats were gradually increased, while the expression level of Ecadherin gradually decreased (p < 0.05). However, the concentrations of TGF-β1, HIF-1, VEGF and α-SMA in renal tissues were significantly reduced, while the expression level of E-adherin was upregulated with time after relief of obstruction (p < 0.05).Conclusion: These findings are of great significance in determining the degree of kidney injury and recovery, and for the development of drugs for the treatment of renal injury.

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Section: Discussionmentioning

confidence: 99%

Differential expressions of TGF-β1, HIF-1, VEGF, α-SMA and E-cadherin in renal tissues of a neonatal rat model of hydronephrosis

Wang¹,

He²,

Zhu³

et al. 2021

Trop. J. Pharm Res

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show abstract

“…However, it seems that they do not represent a risk factor for recurrent UTIs too, and, therefore, we can conclude that, from this point of view, if we can prevent UTIs, we can minimize the risk for progression even in the patients with these genetic variants [ 22 ]. Additionally, as a fact, in children with UTIs, the homozygosity of the C allele of the VEGF-A gene was associated with hypodysplastic renal parenchymal lesions [ 23 ]. Last, but not least, CXC chemokines and their receptors have an important role in providing an inflammatory local response to UTIs [ 24 ].…”

Section: Genetic and Immunological Aspectsmentioning

confidence: 99%

Chronic Kidney Disease, Urinary Tract Infections and Antibiotic Nephrotoxicity: Are There Any Relationships?

et al. 2022

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Chronic kidney disease (CKD) has been a constant burden worldwide, with a prevalence of more than 10% of the population and with mortality reaching 1.2 million deaths and 35.8 million disability-adjusted life years (DALYs) in 2017, as it is claimed by the Global Burden of Diseases. Moreover, an increase in its prevalence is expected in the next years due to a rise in the number of people suffering from obesity, diabetes mellitus and hypertension. On the other hand, with cardiovascular morbidity and mortality showing a downward trend, maybe it is time to focus on CKD, to minimize the preventable risk factors involved in its progression toward end-stage kidney disease (ESKD) and to offer a better quality of life. Another major health burden is represented by infectious diseases, particularly urinary tract infections (UTIs), as it is considered that approximately 40–50% of women and 5% of men will have at least one episode during their lifetime. Additionally, CKD consists of a constellation of immunological and metabolical disturbances that lead to a greater risk of UTIs: increased apoptosis of lymphocytes, elevated levels of tumor necrosis factor α and interleukin 6, which lower the function of neutrophils and increased levels of uremic toxins like p-cresyl sulfate and indoxyl sulfate, which alter the adherence and migration of leukocytes to the sites of injury. Moreover, UTIs can lead to a more rapid decline of kidney function, especially in stages G3-G5 of CKD, with all the complications involved. Last, but not least, antibiotherapy is often complicated in this category of patients, as antibiotics can also negatively affect the kidneys. This review will try to focus on the particularities of the urinary microbiome, asymptomatic bacteriuria and UTIs and the subtle balance between the risks of them and the risks of antibiotherapy in the evolution of CKD.

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“…It has come to our attention that there was a mistake regarding the authors' affiliations in our published article 1 …”

mentioning

confidence: 96%

Corrigendum to the paper Vascular endothelial growth factor–A gene polymorphism is associated with congenital renal lesions in children with urinary tract infections

2023

Acta Paediatrica

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Vascular endothelial growth factor‐A gene polymorphism is associated with congenital renal lesions in children with urinary tract infections

Abstract: In children with UTIs, C allele polymorphism of the VEGF-A gene was associated with hypodysplastic renal parenchymal lesions, which were possibly congenital and existed before the infection.

Cited by 6 publications

References 24 publications

Differential expressions of TGF-β1, HIF-1, VEGF, α-SMA and E-cadherin in renal tissues of a neonatal rat model of hydronephrosis

Differential expressions of TGF-β1, HIF-1, VEGF, α-SMA and E-cadherin in renal tissues of a neonatal rat model of hydronephrosis

Chronic Kidney Disease, Urinary Tract Infections and Antibiotic Nephrotoxicity: Are There Any Relationships?

Corrigendum to the paper Vascular endothelial growth factor–A gene polymorphism is associated with congenital renal lesions in children with urinary tract infections

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