Vascular Endothelial Growth Factor and Brain-Derived Neurotropic Factor Levels in Ischemic Stroke Subject

Hidayat, Andri; Arief, Mansyur; Wijaya, Andi; As’ad, Suryani

doi:10.18585/inabj.v8i2.206

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Finally, a total number of 62 articles were entered into our systematic review. We could not enter 16 articles to any meta-analysis group due to the following reasons; providing delta BDNF instead of exact measures (33), reporting BDNF as a proportion to the control group (34), full text was not found, although the abstract was su cient to extract the descriptive data (35), unsatisfactory data and irresponsive author (missing SD) (36), single study group with no comparison or speci c grouping which did not fall into our meta-analysis categorizations (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48).…”

Section: Resultsmentioning

confidence: 99%

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

Mojtabavi

Shaka²,

Momtazmanesh³

et al. 2021

Preprint

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Background Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. Neuroplasticity is adaptation and reorganization following neuronal damage. Brain-derived neurotrophic factor (BDNF) is a neurotrophin coordinating neuroplasticity after various neurological disorders such as stroke. Methods We conducted a systematic search in the main electronic medical databases through January 2021 and identified studies that measured blood levels of BDNF in patients with stroke. The primary aim was to compare BDNF levels between patients with stroke and healthy controls (HC). The secondary aims included investigation of (1) longitudinal changes in the BDNF levels post-stroke, (2) effects of physical training, (3) repeated transcranial magnetic stimulation (rTMS), and presence of depression on BDNF levels in patients with stroke. Results Among 6243 reviewed records from PubMed, Web of Science, and Scopus, 62 studies were eligible for inclusion. Subjects with stroke, n = 1856, showed lower BDNF levels compared to HC, n=1191 (SMD [95%CI] = -1.04 [-1.49 to -0.58]). No significant difference was detected in the level of BDNF through time points past stroke. BDNF levels were lower in the patients with depression compared to non-depressed subjects (SMD [95%CI] = -0.60 [-1.10 to -0.10]). Physical training had an immediate positive effect on the BDNF levels and not statistically significant effect in the long term; SMD [95%CI] = 0.49 [0.09 to 0.88]) and SMD [95%CI] = 0.02 [-0.43 to 0.47]). Lastly, rTMS showed no effect on the level of BDNF with 0.00 SMD. Conclusions This study confirms that stroke significantly affects the level of BDNF in various domains such as cognition, affect, and motor function. We believe that BDNF could be regarded as a valuable diagnostic biomarker for acute stroke and a potential prognostic biomarker for depression and cognitive deficits.

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Section: Resultsmentioning

confidence: 99%

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

Mojtabavi

Shaka²,

Momtazmanesh³

et al. 2021

Preprint

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“…27 We also collected serum BDNF at day 30 based on another study reported that BDNF level in acute stroke would be increased steadily and reached the highest level after 30 days. 28…”

Section: Demographic and Clinical Characteristicsmentioning

confidence: 99%

Lower serum BDNF as a predictor of post-stroke cognitive impairment in acute ischemic stroke patients

Setyopranoto,

Prodjohardjono,

Sutarni

et al. 2024

F1000Res

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Background Reduced level of serum brain-derived neurotrophic factor (BDNF) in acute stroke patients is associated with poor outcomes. We aimed to identify the role of serum BDNF level as a predictor for post-stroke cognitive impairment (PSCI). Methods This was a prospective study. We recruited acute ischemic stroke patients in Dr. Sardjito General Hospital Yogyakarta, Indonesia followed them up for 90 days (3 months). Serum BDNF was collected at day 5 and day 30 of stroke onset and measured by enzyme-linked immunosorbent assay (ELISA). Montreal Cognitive Assessment (MoCA) was used to measure the cognitive function at 90 days of follow up. Receiver operating characteristic (ROC) curve was conducted to measure the cut-off point of the BDNF level. Factors independently associated with PSCI were analyzed by using stepwise regression. Results Among 89 patients recruited, 60 patients (67.41%) developed PSCI. The mean age of PSCI and non-PSCI patients was 62.7 ± 9.5 and 57.5 ± 8.7, respectively (p = 0.01). Patients with dyslipidemia were less likely to develop PSCI (OR 0.10, 95%CI 0.02-0.51, p < 0.05). In addition, patients with day 5-serum BDNF level < 23.29 ng/mL were five times more likely to develop PSCI compared with their counterparts (OR 5.15, 95%CI 1.26-21.09, p < 0.05). Conclusions Among acute ischemic stroke patients, those with serum BDNF <23.29 ng/mL had a higher risk of developing PSCI. This study suggests that BDNF could be a predictor of PSCI, allowing for earlier detection and better preventive strategies.

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“…(36) Long after a stroke occurs, high BDNF plays a crucial role in regeneration and repair by preserving neuronal and plasticity. (37) Rehabilitative treatment impacts BDNF, although changes in BDNF are not consistently linked to enhanced motor performance. Without active rehabilitative treatment, BDNF levels frequently decline.…”

Section: Effects Of Hiit On Neurons In the Cerebral Cortexmentioning

confidence: 99%

Effect of the High-Intensity Interval Training on BDNF Level in Ischemic Stroke Rat Model on the Recovery of Motor Function

Yani,

Harris,

Jusuf

et al. 2024

Indones Biomed J

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BACKGROUND: Stroke is one of the major causes of disability in the world. High-intensity interval training (HIIT) is known as a novel treatment to promote stroke recovery. However, the results differ in their effects on irisin, which is a regulator of brain-delivered neurotrophic factor (BDNF). Therefore, this study was conducted to investigate the effect of HIIT on BDNF and irisin levels in a rat model of ischemic stroke with middle cerebral artery occlusion (MCAO) induction on recovery motor function.METHODS: Rats were categorized into 4 groups: sham, MCAO, MCAO+moderate-intensity interval training (MIIT), and MCAO+HIIT. MCAO induction was performed to create the ischemic stroke rats model. The motor function was assessed through rotarod and footprint tests. Blood samples were obtained 6 days before MCAO and 14 days after MCAO to examine BDNF and irisin levels with enzyme-linked immunosorbent assay (ELISA). Brain tissue samples were collected 14 days after MCAO for histopathological examination of cortical tissue with hematoxylin-eosin (HE) staining.RESULTS: Rats in the MCAO+HIIT group exhibited an enhanced ability to walk on the rotarod (p=0.016). The stride-length hind paw right in the MCAO+HIIT group demonstrated a noteworthy increase in comparison to baseline value (p=0.036), and the stride-length fore paw right showed a significant increase in both the MCAO+HIIT (p=0.036) and MCAO groups (p=0.034). BDNF significantly improved in the MCAO+MIIT (p=0.043) and MCAO+HIIT groups (p=0.018). The irisin level only showed a significant enhancement in the MCAO+HIIT group (p=0.018).CONCLUSION: HIIT increased motor function, while BDNF level increased with HIIT and MIIT intervention. This preclinical research is useful for supporting the recovery of stroke patients by HIIT intervention.KEYWORDS: BDNF, HIIT, MIIT, irisin, ischemic stroke, MCAO

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Vascular Endothelial Growth Factor and Brain-Derived Neurotropic Factor Levels in Ischemic Stroke Subject

Cited by 7 publications

References 16 publications

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

Lower serum BDNF as a predictor of post-stroke cognitive impairment in acute ischemic stroke patients

Effect of the High-Intensity Interval Training on BDNF Level in Ischemic Stroke Rat Model on the Recovery of Motor Function

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