Vascular endothelial growth factor-B is neuroprotective in an in vivo rat model of Parkinson's disease

Falk, Torsten; Yue, Xu; Zhang, Shiling; McCourt, Alexander D.; Yee, B.; Gonzalez, Robert T.; Sherman, Scott J.

doi:10.1016/j.neulet.2011.03.088

Cited by 52 publications

(36 citation statements)

References 23 publications

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“…VEGF-B treatment reduced stroke volume in a middle cerebral artery ligation model and increased survival of retinal ganglion cells in an optic nerve crush injury model (7), and VEGF-B knockout mice suffered severe strokes and exacerbated retinal ganglion cell death in both injury models (7)(8)(9). VEGF-B has also been used with promising results in Parkinson's disease (10) and amyotrophic lateral sclerosis models (11).…”

mentioning

confidence: 99%

VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

Guaiquil

Pan

Karagianni

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

104

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Significance Peripheral nerve injury is a major neurological disorder that can cause multiple motor and sensory disturbances. In this study we found that VEGF-B can be used as a previously unidentified therapeutic for treating peripheral nerve injury. We demonstrated that VEGF-B stimulated nerve regeneration and enhanced the recovery of both tissue sensation and the ability of nerves to enhance healing of innervated tissue. The physiologic relevance of VEGF-B is demonstrated by our findings showing that mice lacking VEGF-B have impaired nerve regeneration and that nerve injury resulted in increased endogenous expression of VEGF-B. We discover that VEGF-B induces strong elongation and branching of neurons and requires specific transmembrane receptors as well as activation of a complex intracellular signaling.

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mentioning

confidence: 99%

VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

Guaiquil

Pan

Karagianni

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

104

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“…In another study, VEGF-B 186 was used to test its neuroprotective effect in a PD model since it is more diffusable and hardly binds to extracellular matrix than VEGF-B 167 (Olofsson et al, 1996b;Poesen et al, 2008). In this study, a single dose of VEGF-B 186 (3µg/rat) rescued dopaminergic neurons from death in the caudal sub region of substantia nigra in rats (Falk et al, 2011). Thus, as a potent neuronal and vascular protective factor, VEGF-B may have therapeutic implications in PD treatment.…”

Section: Parkinson's Diseasementioning

confidence: 81%

Can VEGF-B Be Used to Treat Neurodegenerative Diseases?

Li¹,

Kumar²,

Lee³

et al. 2011

Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring

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“…Indeed, the up-regulated transcriptional activation of VEGF-B in response to midbrain neurodegenerative challenges was observed in Parkinson's Disease (PD), and VEGF-B produced by astrocytes and motor neurons exerted a neuroprotective affect. 22 , 100 Preclinical studies in PD 101 and amyotrophic lateral sclerosis model 22 had shown promising results, despite the lack of clinical studies. VEGF-B treatment rescued brain neurons from apoptosis in stroke mouse 21 and protected cultured primary motor neurons against degeneration, 22 with little retinal neovascularization effect.…”

Section: Introductionmentioning

confidence: 99%

“…The co-expression of VEGF-B with FAs oxidation relative mitochondrial genes was observed in rat midbrain, suggesting the mitochondria as the target site. 102 Moreover, VEGF-B possessed the considerably robust survival ability, 101 , 102 as a single VEGF-B 186 protein treatment at a dose of 3 mg per rat partially protected dopaminergic fibers in the striatum and rescued the dopaminergic neurons in the caudal sub-region of the substantianigra. 101 …”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor-B: Impact on physiology and pathology

Zhu

Gao

et al. 2017

Cell Adhesion & Migration

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Angiogenesis plays an important role in controlling tissue development and maintaining normal tissue function. Dysregulated angiogenesis is implicated in the pathogenesis of a variety of diseases, particularly diabetes, cancers, and neurodegenerative disorders. As the major regulator of angiogenesis, the vascular endothelial growth factor (VEGF) family is composed of a group of crucial members including VEGF-B. While the physiological roles of VEGF-B remain debatable, increasing evidence suggests that this protein is able to protect certain type of cells from apoptosis under pathological conditions. More importantly, recent studies reveal that VEGF-B is involved in lipid transport and energy metabolism, implicating this protein in obesity, diabetes and related metabolic complications. This article summarizes the current knowledge and understanding of VEGF-B in physiology and pathology, and shed light on the therapeutic potential of this crucial protein.

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Vascular endothelial growth factor-B is neuroprotective in an in vivo rat model of Parkinson's disease

Cited by 52 publications

References 23 publications

VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

Can VEGF-B Be Used to Treat Neurodegenerative Diseases?

Vascular endothelial growth factor-B: Impact on physiology and pathology

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