Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: Concurrent expression in cancer cells from primary tumour and metastatic lymph node

Saintigny, Pierre; Kambouchner, Marianne; Ly, Madani; Gomes, Noëlia; Sainte-Cathérine, Odile; Vassy, Roger; Czernichow, S.; Letoumelin, P.; Breau, Jean Luc; Bernaudin, J.-F.; Kraemer, Michel

doi:10.1016/j.lungcan.2007.06.021

Cited by 62 publications

(62 citation statements)

References 34 publications

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“…At present, some studies suggest that (Poon et al, 2001), to some extent, the serum levels of VEGF expression reflect the staging and prognosis of patients with esophageal cancer. In this study, our results showed that the serum levels of VEGF in patients with esophageal cancer were higher than that of normal controls, the protein expression of VEGF in tumor tissue was related to lymph node metastasis, and that the TNM stage and therapeutic effect of chemoradiotherapy were consistent with the results of relevant reports at home and abroad (Imdahl et al, 2002;Saintigny et al, 2007). VEGF expression may be one of the indicators reflecting the progress of esophageal cancer and is a potential predictor of the therapeutic effect.…”

Section: Discussionsupporting

confidence: 85%

Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang

et al. 2014

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ABSTRACT. This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esophageal squamous cell carcinoma, and to analyze the relationship between biomarkers and clinical pathology and curative effects. Our findings were as follows: 1. The serum levels of VEGF and ES in Han patients were obviously higher than those of Uygur and Kazakh patients (P < 0.05). The VEGF positive rate in patients at a later clinical stage was higher than that of the patients at an earlier clinical stage (stages II-IV were 14.29, 50.00, and 50.00%, respectively, P < 0.05), meanwhile it was higher than that of patients without lymph node metastases (78.13 vs 25.00%, P < 0.05). The curative effective rate of patients with negative expression of VEGF was higher than that of patients with positive expression of VEGF (74.67 vs 41.40%, P < 0.05). 2. The expression of EGFR protein in male patients was higher than that of female patients (69.77 vs 35.29%, P < 0.05). Before treatment, the serum EGFR level in patients was higher than the normal group (P < 0.05). 3. The serum ES level in patients before and after treatment was significantly higher than in the normal group (P < 0.05). 4. The HER-2 positive rate in higher differentiated tumor tissue was lower than that in lower differentiated tumor tissue. (The positive rate of I, II, III grade was 70.00, 30.00, and 20.00%, respectively, P < 0.05). 5. The NF-κB positive rate in patients with lymph node metastases was higher than that of patients without lymph node metastases (65.63 vs 39.27%, P < 0.05), meanwhile median survival in the latter group was higher than that of the former group (P < 0.05). Our data suggest that the expression of VEGF and ES were different in Uygur, Han, and Kazakh patients in Xinjiang. The combined detection of tumor markers in serum and tissue is of direct significance for tumor therapy.

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Section: Discussionsupporting

confidence: 85%

Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang

et al. 2014

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“…In addition, studies have shown that numerous cancer cells express Flt-4 (i.e., VEGFR-3), which plays an important role in tumor progression. Clinical trials in many human malignant tumors have shown that VEGFR-3 expression in cancer cells is correlated to the clinical stage of cancer in patients, the degree of cell differentiation, lymph node metastasis and patient prognosis (7)(8)(9). Van Trappen et al reported that VEGFR-3/Flt-4 expression levels changed with the progression of cervical intraepithelial carcinoma into cervical cancer (10).…”

Section: Clinicopathological Factors N Vegfr-3/flt-4 Mvd [Mean (Sd)] mentioning

confidence: 99%

Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer

Zhang¹,

Heng²,

Zhang³

2010

Oncology Letters

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“…Early studies have suggested that VEGF-C can promote the growth of new LVs and regional metastasis by binding to their receptor tyrosine kinase VEGFR-3, which was found to be densely expressed in lymphatic endothelial cells (25,26). Studies with human or animal tumor models have demonstrated that malignant tumor cells themselves can secrete high levels of VEGF-C (27), and this overexpression of tumor-derived VEGF-C may play an important role in the occurrence of intratumoral lymphangiogenesis leading to the dissemination of tumor cells to regional lymph nodes (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer

et al. 2016

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Abstract. Colorectal cancer (CRC) is one of the most common malignancies worldwide. The majority of patients are not suitable for surgery due to the presence of metastatic disease at the time of diagnosis, which has led to a high mortality rate for patients with CRC. Lymphangiogenesis, formation of new lymphatic vessels, plays an critical role in cancer progression particularly in cancer metastasis. Vascular endothelial growth factor-C (VEGF-C) has been previously demonstrated to play a pivotal role in cancer metastasis and therefore has become an attractive target for anticancer treatments. Pien Tze Huang (PZH) is a well-known traditional Chinese formula, which has exhibited significant therapeutic effects against CRC. However, the molecular mechanisms underlying its anticancer effects, particularly in regards to antimetastasis activity, still require further elucidation. In the present study, we evaluated the effects of PZH on cell migration and VEGF-C expression using various human CRC cell lines. Moreover, using a VEGF-Cstimulated human lymphatic endothelial cell (HLEC) model, we demonstrated that PZH suppresses lymphangiogenesis by attenuating cell migration and tube formation. This indicates that PZH possesses significant antimetastatic activity. Moreover, suppression of lymphangiogenesis by PZH via the downregulation of VEGF-C may be a potential molecular mechanism by which PZH inhibits metastasis in CRC.

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Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: Concurrent expression in cancer cells from primary tumour and metastatic lymph node

Cited by 62 publications

References 34 publications

Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang

Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang

Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer

Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer

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