Vascular endothelial growth factor G+405C polymorphism may contribute to the risk of developing papillary thyroid carcinoma

Abstract

In G+405C polymorphism, the frequencies of C allele (related with increased VEGF production) and combined CG+CC genotype were found to be higher (3.5 and 5-fold, respectively) among patients with PTC than controls (P<.001). However, VEGF T-460C and A-2578C polymorphisms are not associated with PTC risk. There was no relationship between VEGF polymorphisms and clinical/laboratory parameters of PTC. Haplotype analysis demonstrated that there was a strong linkage disequilibrium (LD) between -460/-2578 (D'=.89, r =.79), weak LD between +405/-460 (D'=.422, r =.035), and +405/-2578 (D'=.43, r =.038) locuses. Additionally, the +405/-460/-2578 GTA haplotype was found to be protective, whereas CTA haplotype to be related with increased PTC risk. As a conclusion, we suggest that VEGF G+405C polymorphism is associated with increased risk of PTC.

Metabolic Reprogramming in Thyroid Carcinoma

“…VEGF recruits new microvessels that allow the delivery of nutrients and expansion of the tumor mass. Some previous studies have indicated that VEGF as a risk factor of developing PTC or tumor progression ( 79 , 80 ).…”

The relationship between VEGF-460(T>C) polymorphism and cancer risk: A systematic review and meta-analysis based on 46 reports

“…54 studies comprising 60 reports were enrolled initially, published literature [19–68] and gray literature. [69–72] We included 46 English-language articles and 8 Chinese-language articles.…”

“…Numerous institutions have performed extensive studies to demonstrate the relationship between SNPs in VEGF and cancer, especially for VEGF-460(T/C). [19–78] However, different and even contradictory results were obtained. Several investigators have conducted meta-analyses to evaluate this link comprehensively.…”

Association of candidate genes (ALR2, RAGE, and VEGF) polymorphisms with diabetic retinopathy in type 2 diabetic patients of Khyber Pakhtunkhwa, Pakistan

“…Several groups have con rmed the association of VEGF SNPs (− 460T/C, + 405G/C, and + 936C/T) with increased VEGF expression, and a signi cant increase activity is observed in the VEGF promoter region in the presence of the + 405/-460 polymorphisms [14]. Still, because of ethnic and regional differences and other differences, the results of previous studies have not been reliable.…”