Vascular endothelial growth factor gene +936 C/T polymorphism is associated with preeclampsia in Korean women

Shim, Jae-Yoon; Jun, Jong Kwan; Jung, Bok-Kyung; Kim, Sung Hoon; Won, Hye‐Sung; Lee, Pil Ryang

doi:10.1016/j.ajog.2007.06.045

Cited by 51 publications

(37 citation statements)

References 29 publications

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“…A blood sample was taken from each woman, and genomic DNA was extracted from buffy coat cells as described 18 . Samples were genotyped for the UTS‐II SNP using a validated TaqMan SNP Genotyping Assay [Applied Biosystems Inc. (ABI), Foster City, CA, USA], employing predesigned primers and probes for the UTS‐II gene (rs228648) (ABI).…”

Section: Methodsmentioning

confidence: 99%

Urotensin-II 143 G/A Polymorphism is not Associated with the Risk of Preeclampsia in Korean Women

Shim

Jung

et al. 2011

American Journal of Reproductive Immunology

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Section: Methodsmentioning

confidence: 99%

Urotensin-II 143 G/A Polymorphism is not Associated with the Risk of Preeclampsia in Korean Women

Shim

Jung

et al. 2011

American Journal of Reproductive Immunology

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“…Finally, Shim et al [32] have characterized another polymorphism of VEGF in Korean pregnant women using PCR and restriction fragment length polymorphism assay. The VEGF +936 C>T has been located in the 3′-unstranslated region (UTR), and it has been associated with PE.…”

Section: The Genetic Componentmentioning

confidence: 99%

Pathogenesis of Preeclampsia: The Genetic Component

Valenzuela

Pérez-Sepúlveda

Torres

et al. 2012

Journal of Pregnancy

110

100

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Preeclampsia (PE) is one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40% of births delivered before 35 weeks of gestation. PE begins with inadequate trophoblast invasion early in pregnancy, which produces an increase in oxidative stress contributing to the development of systemic endothelial dysfunction in the later phases of the disease, leading to the characteristic clinical manifestation of PE. Numerous methods have been used to predict the onset of PE with different degrees of efficiency. These methods have used fetal/placental and maternal markers in different stages of pregnancy. From an epidemiological point of view, many studies have shown that PE is a disease with a strong familiar predisposition, which also varies according to geographical, socioeconomic, and racial features, and this information can be used in the prediction process. Large amounts of research have shown a genetic association with a multifactorial polygenic inheritance in the development of this disease. Many biological candidate genes and polymorphisms have been examined in their relation with PE. We will discuss the most important of them, grouped by the different pathogenic mechanisms involved in PE.

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“…Many polymorphisms have been reported in the promoter and the 5′‐ and 3′‐untranslated regions (UTRs) of the VEGF gene. These polymorphisms are associated with various diseases, including recurrent pregnancy loss, pre‐eclampsia, and preterm delivery 18–24 …”

Section: Introductionmentioning

confidence: 99%

ORIGINAL ARTICLE: Association Study of Vascular Endothelial Growth Factor and Polymorphisms of its Gene with Ectopic Pregnancy

Elito

Daher

Silva

et al. 2010

American J Rep Immunol

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Vascular endothelial growth factor gene +936 C/T polymorphism is associated with preeclampsia in Korean women

Cited by 51 publications

References 29 publications

Urotensin-II 143 G/A Polymorphism is not Associated with the Risk of Preeclampsia in Korean Women

Urotensin-II 143 G/A Polymorphism is not Associated with the Risk of Preeclampsia in Korean Women

Pathogenesis of Preeclampsia: The Genetic Component

ORIGINAL ARTICLE: Association Study of Vascular Endothelial Growth Factor and Polymorphisms of its Gene with Ectopic Pregnancy

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