2010
DOI: 10.1038/jcbfm.2009.271
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Vascular Endothelial Growth Factor Increases Neurogenesis after Traumatic Brain Injury

Abstract: Activation of endogenous stem cells has been proposed as a novel form of therapy in a variety of neurologic disorders including traumatic brain injury (TBI). Vascular endothelial growth factor (VEGF) is expressed in the brain after TBI and serves as a potent activator of angiogenesis and neurogenesis. In this study, we infused exogenous VEGF into the lateral ventricles of mice for 7 days after TBI using mini-osmotic pumps to evaluate the effects on recovery and functional outcome. The results of our study show… Show more

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Cited by 169 publications
(145 citation statements)
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“…Damaged tissue volume was calculated as previously described by dividing the volume of the injured left hemisphere by that of the right, undamaged hemisphere. 20 Results are expressed as a percentage of hemispheric tissue (n ¼ 9 to 10 mice/group).…”
Section: Lesion Volumementioning
confidence: 99%
“…Damaged tissue volume was calculated as previously described by dividing the volume of the injured left hemisphere by that of the right, undamaged hemisphere. 20 Results are expressed as a percentage of hemispheric tissue (n ¼ 9 to 10 mice/group).…”
Section: Lesion Volumementioning
confidence: 99%
“…Delivery of VEGF to the lateral FPI model has been shown to significantly increase the number of BrdU labeled adult-born neurons in the adult hippocampus, but does not change the number of BrdU labeled newborn cells per se (Lee&Agoston, 2010) suggesting that in the hippocampus VEGF predominantly mediates survival of adult-born neurons rather than progenitor cell proliferation. In contrast, Thau-Zuchman and colleagues (Thau-Zuchman, et al, 2010) observed an increase in the number of proliferating cells in the SVZ and the perilesion cortex following infusion of VEGF into the lateral ventricles of mice after TBI. Further, while functional outcome was significantly improved in mice treated with VEGF compared to vehicle treated animals following TBI, fate analysis demonstrated that most newborn cells differentiated into astrocytes and oligodendroglia, and only a few cells differentiated into neurons (Thau-Zuchman, et al, 2010).…”
Section: Traumatic Brain Injurymentioning
confidence: 85%
“…In contrast, Thau-Zuchman and colleagues (Thau-Zuchman, et al, 2010) observed an increase in the number of proliferating cells in the SVZ and the perilesion cortex following infusion of VEGF into the lateral ventricles of mice after TBI. Further, while functional outcome was significantly improved in mice treated with VEGF compared to vehicle treated animals following TBI, fate analysis demonstrated that most newborn cells differentiated into astrocytes and oligodendroglia, and only a few cells differentiated into neurons (Thau-Zuchman, et al, 2010). The effect of mitogen support on hippocampal neurogenesis following TBI has also been examined using transgenic models.…”
Section: Traumatic Brain Injurymentioning
confidence: 85%
“…However, many experimental studies employing recombinant forms of AGFs support the hypothesis, as discussed in detail elsewhere [6,9]. For example, injection of VEGF or FGF into the normal cerebral cortex or ventricle of animals elicits cortical angiogenesis [10,11]. Occlusion of the femoral artery in an animal's hind limb evokes ischemia there, which is relieved by local injections of AGFs [12].…”
Section: Cause and Effectmentioning
confidence: 94%