Vascular Endothelial Growth Factor Levels (Vegf) in Gingival Biopsies of Patients With Chronic or Aggressive Periodontitis

Önder, Canan; Kurgan, Şivge; BALCI2, Nur; Güney, Zeliha; Serdar, Muhittin; GUNHAN4, Omer; Günhan, Meral

doi:10.21506/j.ponte.2016.7.19

Cited by 2 publications

(1 citation statement)

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“…VEGF in the GCF from areas affected by the periodontal disease was increased compared with healthy sites . Previously, we found that the VEGF‐A values were increased in both GAgP and CP, and the highest VEGF‐A value was identified in the GAgP group . VEGF levels correlate with the healing of the periodontal tissues .…”

Section: Discussionmentioning

confidence: 83%

A disintegrin‐like and metalloproteinase with thrombospondin‐1 (ADAMTS‐1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor‐A, hypoxia‐inducible factor‐1α, and clinical parameters in patients with advanced periodontitis

Tayman

Kurgan

Önder

et al. 2019

Journal of Periodontology

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Background ADAMTS (a disintegrin‐like and metalloproteinase with thrombospondin) are a family of proteinases that are structurally similar to the family of matrix metalloproteinases with critical roles in damage and repair of the extracellular matrix. Their functions are closely related to inflammation, hypoxia, and vascularization. Our aim was to determine levels of ADAMTS‐1 in gingival crevicular fluid (GCF) in patients with advanced periodontal diseases and identify their association with hypoxia‐inducible factor‐1alpha (HIF‐1α), vascular endothelial growth factor (VEGF‐A), and clinical parameters of periodontitis. Methods The study consisted of three groups: healthy individuals (control; n = 20), generalized chronic periodontitis (CP; n = 21), and generalized aggressive periodontitis (GAgP; n = 20). Clinical parameters were measured. Levels of ADAMTS‐1, VEGF‐A, and HIF‐1α in GCF and serum were quantified by enzyme‐linked immunosorbent assay (ELISA) and reported as total amounts and concentration. Results ADAMTS‐1 total amount in GCF were significantly higher in patients with CP and GAgP compared with healthy individuals (P < 0.05). HIF‐1α total amount in GCF were also higher in periodontitis groups compared with the control group (P < 0.05). GCF total VEGF‐A content was significantly higher in the GAgP group compared with the CP and the controls (respectively; P = 0.023, P = 0.003). There was a significant correlation between ADAMTS‐1, VEGF‐A, and HIF‐1α levels in the GCF and clinical periodontal parameters (probing depth [PD], bleeding on probing [BOP], and clinical attachment loss (CAL); P < 0.05). Conclusion ADAMTS‐1 may play a role in advanced periodontal disease pathogenesis in correlation with tissue hypoxia and vascularization.

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Section: Discussionmentioning

confidence: 83%