1995
DOI: 10.1159/000267567
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Vascular Endothelial Growth Factor Plays a Role in Hyperpermeability of Diabetic Retinal Vessels

Abstract: In rat diabetic retinas, we immunohistochemically looked for vascular endothelial growth factor (VEGF) which is also known as vascular permeability factor (VPF). In nondiabetic retinas, VEGF immunoreactivity was weak and restricted to the nerve fiber and ganglion cell layers. On the other hand, in diabetic retinas, VEGF immunoreactivity was markedly increased and was observed in all layers of the retina, especially in the perivascular area. Hyperpermeability of these vessels was confirmed by immunohistochemica… Show more

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Cited by 186 publications
(79 citation statements)
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“…in the absence of neovascularisation [30][31][32][33][34][35]. Interestingly, other formulations of α-lipoic acid, given for shorter periods, produced complete inhibition of VEGF in the diabetic retina [10].…”
Section: Discussionmentioning
confidence: 99%
“…in the absence of neovascularisation [30][31][32][33][34][35]. Interestingly, other formulations of α-lipoic acid, given for shorter periods, produced complete inhibition of VEGF in the diabetic retina [10].…”
Section: Discussionmentioning
confidence: 99%
“…10 The link between the systemic abnormalities of diabetes and changes in the blood retinal barrier is poorly understood.…”
Section: Pathogenesis Of Diabetic Maculopathymentioning
confidence: 99%
“…[4][5][6] Notably, inhibition of VEGF activity can prevent neovascularization and blood-retinal barrier breakdown in animal models. [6][7][8][9] Recently, insulin has been reported to increase the expression of VEGF in multiple cell types, including epithelial cells, 10 fibroblasts, 11 and other cells. 12 Moreover, insulin-induced VEGF expression was thought to be associated with the transient worsening of diabetic retinopathy after acute intensive insulin therapy.…”
Section: Introductionmentioning
confidence: 99%