Vascular endothelial growth factor profile and Vitamin D level in Systemic Sclerosis Egyptian patients

Gharbawy, Nermin Hassan El; Sheha, Dina Sayed; Bawady, Somia; Leithy, Sally A El

doi:10.55133/eji.280117

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…We identified 180 studies electronically and manually, 29 of which were selected for full-text review based on the title and abstract, and 8 of which were excluded because they had no data on vitamin D level, duplicate data, or data on review. Ultimately, 21 articles met the inclusion criteria 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 . In total, 21 studies were included in the meta-analysis, which comprised 1,399 patients with SSc and 1,311 controls ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The immunosuppressive and immunoregulatory effects of vitamin D may affect the pathogenetic processes of SSc, including immunity, peripheral vasculopathy, and fibrosis 12 . Studies investigating the relationship between vitamin D deficiency and SSc, as well as blood vitamin D levels in patients with SSc compared to healthy controls, have reported conflicting results 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 . This disparity might be attributed to small sample sizes, low statistical power, and/or clinical heterogeneity 34 35 36 .…”

Section: Introductionmentioning

confidence: 99%

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Circulating Vitamin D Levels in Patients With Systemic Sclerosis: a Meta-Analysis

Lee,

Song

2023

Aktuelle Rheumatologie

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Objective This study aimed to evaluate the relationship between circulating vitamin D levels and systemic sclerosis and to establish an association between vitamin D deficiency and systemic sclerosis. Methods We performed a meta-analysis comparing the plasma/serum vitamin D levels and vitamin D deficiency between patients with systemic sclerosis and healthy controls and examined correlation coefficients between circulating vitamin D levels and the Rodnan score. Results Twenty-one studies involving 1,399 patients with systemic sclerosis and 1,311 controls were included. The systemic sclerosis group had significantly lower vitamin D levels than the control group. Stratification by ethnicity demonstrated significantly decreased vitamin D levels in patients with systemic sclerosis among European, Asian, Arab, Latin American, and mixed populations. Stratification by age, sex, and/or body mass index revealed significantly lower vitamin D levels in the systemic sclerosis group regardless of the adjustment. Subgroup analysis by sample size revealed significantly lower vitamin D levels in the systemic sclerosis group by small (n<100) and large sample numbers (n>100). Stratification by publication year revealed significantly lower vitamin D levels in the systemic sclerosis group in both recent and old publication years. However, no significant difference in vitamin D levels was observed between diffuse and limited types of systemic sclerosis. Vitamin D deficiency was significantly associated with systemic sclerosis. The meta-analysis of correlation coefficients revealed a tendency of inverse correlation between circulating vitamin D levels and the Rodnan score. Conclusions Patients with systemic sclerosis had lower circulating vitamin D levels and higher vitamin D deficiency and there was a tendency of inverse correlation between circulating vitamin D levels and the Rodnan score.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating Vitamin D Levels in Patients With Systemic Sclerosis: a Meta-Analysis

Lee,

Song

2023

Aktuelle Rheumatologie

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Vitamin D association with systemic sclerosis and its clinical features: A systematic review, meta-analysis, and meta-regression

Dhaouadi,

Riahi,

Ben Abdallah

et al. 2024

Journal of Scleroderma and Related Disorders

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Objectives: The aim of this review was to summarize existing data on the contribution of Vitamin D level and/or deficiency/insufficiency to systemic sclerosis susceptibility and its clinical features. Methods: An electronic literature search for eligible studies among all papers published prior to 30 June 2024 was conducted through PubMed, EMBASE, Web of science, and Scopus databases. Meta-analyses estimating pooled raw mean differences, odds ratios, and Pearson r together with subgroup analyses and meta-regressions were performed for the association of Vitamin D with susceptibility to systemic sclerosis and disease presentation. Results: Combined analysis revealed a significant decrease in Vitamin D level in systemic sclerosis patients comparatively to healthy controls, with raw mean differences 95% CI = −11.68 [−15.43 to −7.92] ng/mL, p < 1 E-10. Likewise, Vitamin D insufficiency (Vitamin D < 30 ng/mL) and deficiency (<10 ng/mL) were significantly associated with systemic sclerosis; odds ratios 95% CI = 3.58 [2.59–4.95], p < 1 E-10 and odds ratios 95% CI = 7.67 [3.97–14.83], p < 1 E-10, respectively. Moreover, decreased Vitamin D level was significantly associated with interstitial lung disease occurrence (raw mean differences 95% CI = −3.61 [−6.93 to −0.3], p = 0.003), while Vitamin D deficiency was associated with increased systolic pulmonary arterial pressure, raw mean differences (95% CI = 4.17 [1.44–6.89], p = 0.003). Besides, Vitamin D level was negatively correlated with the modified Rodnan skin score, r (95% CI = −0.26 [−0.44 to −0.08], p = 0.004). Conversely, Vitamin D level was significantly increased in systemic sclerosis patients with cutaneous calcinosis, raw mean differences (95% CI = 4.18 [1.07–7.28], p = 0.008). Conclusion: This meta-analysis showed that decreased Vitamin D level was associated with susceptibility to systemic sclerosis, interstitial lung disease occurrence, increased systolic pulmonary arterial pressure, and higher modified Rodnan skin score. Conversely, calcinosis was found to be associated with increased Vitamin D level. Registration: This review has been registered on PROSPERO: CRD42024565045, available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024565045

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Vascular endothelial growth factor as a potential biomarker in systemic sclerosis: a systematic review and meta-analysis

Zinellu,

Mangoni

2024

Front. Immunol.

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IntroductionSystemic sclerosis (SSc), a chronic autoimmune condition, is characterized by microvascular dysfunction, ineffective angiogenesis, and fibrosis. The identification of robust biomarkers reflecting these processes may assist in clinical management and lead to the discovery of new therapies. We sought to address this issue by conducting a systematic review and meta-analysis of studies investigating one such biomarker, vascular endothelial growth factor (VEGF), in SSc patients and healthy controls and in SSc patients with localized or diffuse disease, different video capillaroscopy patterns (early, active, or late), and presence or absence of complications.MethodsWe searched PubMed, Scopus, and Web of Science from inception to 15 May 2024. We assessed the risk of bias and the certainty of evidence using the JBI checklist for analytical studies and GRADE, respectively.ResultsIn 42 eligible studies, compared to controls, patients with SSc had significantly higher plasma or serum VEGF concentrations (standard mean difference, SMD=0.93, 95% CI 0.71 to 1.15, p<0.001; moderate certainty). In further analyses, VEGF concentrations were significantly higher in SSc patients with diffused disease than those with localized disease (SMD=0.30, 95% CI 0.01 to 0.59, p=0.046; very low certainty), in patients with late vs. active video capillaroscopy pattern (SMD=0.35, 95% CI 0.09 to 0.61, p=0.008; very low certainty), and in patients with pulmonary hypertension than those without (SMD=0.93, 95% CI 0.34 to 1.53, p=0.002; very low certainty). By contrast, no significant differences were observed between SSc patients with and without digital ulcers, interstitial lung disease, and telangiectasias, whereas limited evidence was available for alveolitis. Meta-regression and subgroup analysis of studies investigating VEGF in SSc patients and controls showed no significant associations between the effects size and various patient and study characteristics, including SSc duration and use of corticosteroids, immunosuppressors and vasodilators. By contrast, significant associations were observed with the geographical location where the study was conducted.DiscussionThe results of this systematic review and meta-analysis suggest that VEGF can be useful in the assessment and management of SSc and in the identification of novel therapeutic strategies in this patient group.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42024552925.

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Vascular endothelial growth factor profile and Vitamin D level in Systemic Sclerosis Egyptian patients

Cited by 3 publications

References 26 publications

Circulating Vitamin D Levels in Patients With Systemic Sclerosis: a Meta-Analysis

Circulating Vitamin D Levels in Patients With Systemic Sclerosis: a Meta-Analysis

Vitamin D association with systemic sclerosis and its clinical features: A systematic review, meta-analysis, and meta-regression

Vascular endothelial growth factor as a potential biomarker in systemic sclerosis: a systematic review and meta-analysis

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