Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts

Wongtrakul, Saichol; Bishop, Allen T.; Friedrich, Patricia F.

doi:10.1053/jhsu.2002.31158

Cited by 32 publications

(26 citation statements)

References 28 publications

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“…Only 42 percent of grafts have partial longitudinal neovascularization by the third postoperative day. 5 Vascular sprouting from the surrounding tissues is superior to that of longitudinal revascularization. 6,7 Thus, the status of the recipient bed is important: conventional nerve grafts, if of small diameter, can be used on a wellvascularized recipient bed.…”

mentioning

confidence: 99%

Vascularized Ulnar Nerve Graft: 151 Reconstructions for Posttraumatic Brachial Plexus Palsy

Terzis

Kostopoulos

2009

Plastic and Reconstructive Surgery

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mentioning

confidence: 99%

Vascularized Ulnar Nerve Graft: 151 Reconstructions for Posttraumatic Brachial Plexus Palsy

Terzis

Kostopoulos

2009

Plastic and Reconstructive Surgery

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“…to use a continuous infusion pump rather than our I I78 Research 23 (2005) 1 172-11 78 previously described intravenous dosing every six hours for 72 h because the half-life of ATL146e has been found to be short, and a continuous infusion provides sustained systemic levels of the drug for up to 72 h. The use of the ALZET subcutaneous pump has been well documented in the literature as an effective method of drug delivery [6,10,20]. Once again the use of an animal model does not completely mimic a clinical scenario, but is a very effective method for testing in this scenario.…”

Section: Discussionmentioning

confidence: 99%

An adenosine A_2A receptor agonist reduces interleukin‐8 expression and glycosaminoglycan loss following septic arthrosis

Cohen

Leo

Baer

et al. 2005

Journal Orthopaedic Research

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The purpose of this study was to determine whether an adenosine AZA receptor agonist (ATL146e) might augment the current treatment regimen of antibiotics plus irrigation and debridement to prevent the arthritic effects associated with joint sepsis. Staph-~ZOCOCCUS aureus bacteria were injected into knees of rabbits, which were divided into 4 treatment groups (12 rabbits per group): no treatment, ATL146e only, antibiotics only, or antibiotics plus ATL146e. Analysis at days 1,3, and 7 consisted of gross joint appearance, synovial fluid, serum, histologic, immunohistochemical, and biochemical analysis.Synovial fluid cultures at day 7 were negative in all antibiotic and antibiotic plus ATL146e treated knees indicating clearance of bacteria. Average WBC counts from synovial fluid aspirates significantly decreased with treatment of antibiotics alone and antibiotics plus ATL146e. Treatment with antibiotics plus ATL146e significantly decreased the Interleukin-8 content when compared to other treatment groups (p < 0.001) indicating inflammatory response suppression. Histologic grading resulted in notably improved scores in the antibiotics plus ATL146e group compared to other treatment groups (p < 0.001). Glycosaminoglycan assay values were significantly greater in the ATL146e plus antibiotics group compared to the untreated control group (p < 0.04) indicating chondroprotection.agonist in combination with antibiotic therapy diminishes joint WBC chemotaxis and reduces joint inflammation, while not compromising the clearance of intraarticular bacteria in a rabbit model. Early bacterial clearance with modulation of the inflammatory response appears to prevent the early degradative effects of joint sepsis.

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“…This technique has been previously described [22,26]. A 20-gauge catheter was introduced through the right carotid artery and positioned in the left ventricle for microsphere administration.…”

Section: Determination Of Bone Bloodflowmentioning

confidence: 99%

Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone

Katsube

Bishop

Simari

et al. 2005

Journal Orthopaedic Research

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Avascular necrosis of bone is a relatively common clinical condition caused by inflammatory conditions, steroid or other drug use, and trauma that affect many different sites in man. Revascularization of the necrotic bone is slow to occur, often resulting in bone resorption and eventual collapse of the involved bone. Rapid revascularization and subsequent bone remodeling may lead to improved outcomes.Surgical revascularization with arterovenous bundles (AV bundles) or vascularized bone grafts results in neoangiogenesis and bone remodeling. Gene transfer of an angiogenic factor to the vessel wall may be an additional strategy to further accelerate this process. In this study, we examined the effectiveness of vascular endothelial growth factor (VEGF) gene transfer to augment surgical revascularization of necrotic bone. An adenoviral vector, either with the VEGF gene (VEGF-A) or identical virus without the cDNA VEGF insert (ADV-AE1) was used to transduce endothelial cells in rabbit saphenous arteries. The artery was then placed with its venae comitantes as an AV bundle into necrotic iliac crest bone in vivo. Angiogenesis in the necrotic bone was quantified by bone blood flow measurement and assessment of vessel density following microangiography. The extent of neoangiogenesis was significantly greater in the VEGF group than the control group at 1 week postoperatively.

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Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts

Cited by 32 publications

References 28 publications

Vascularized Ulnar Nerve Graft: 151 Reconstructions for Posttraumatic Brachial Plexus Palsy

Vascularized Ulnar Nerve Graft: 151 Reconstructions for Posttraumatic Brachial Plexus Palsy

An adenosine A_2A receptor agonist reduces interleukin‐8 expression and glycosaminoglycan loss following septic arthrosis

Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone

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Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts

Cited by 32 publications

References 28 publications

Vascularized Ulnar Nerve Graft: 151 Reconstructions for Posttraumatic Brachial Plexus Palsy

Vascularized Ulnar Nerve Graft: 151 Reconstructions for Posttraumatic Brachial Plexus Palsy

An adenosine A2A receptor agonist reduces interleukin‐8 expression and glycosaminoglycan loss following septic arthrosis

Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone

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An adenosine A_2A receptor agonist reduces interleukin‐8 expression and glycosaminoglycan loss following septic arthrosis