Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia: A case-control study

Gannoun, Marwa Ben Ali; Al-Madhi, Safa A.; Zitouni, Hédia; Raguema, Nozha; Meddeb, S.; Ali, Feten Hachena Ben; Mahjoub, Touhami; Almawi, Wassim Y.

doi:10.1016/j.cyto.2017.06.010

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…The results of these previous studies indicate that VEGF may be a key regulator in angiogenesis and decidualization of the endometrium, which are essential processes for the maintenance of a successful pregnancy. VEGF is located on chromosome 6p21.3 and is comprised of eight exons (11). Several single nucleotide polymorphisms (SNPs) have been previously detected in VEGF, including -2578C>A, -1154G>A, -634C>G and 936C>T, which are associated with altered VEGF expression (12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

et al. 2017

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Abstract. The objective of the present study was to investigate the association between recurrent implantation failure (RIF) and vascular endothelial growth factor (VEGF) gene polymorphisms that are associated with various female infertility disorders. A total of 116 women diagnosed with RIF and 218 control subjects were genotyped for the VEGF -2578C>A, -1154G>A, -634C>G and 936C>T polymorphisms using a polymerase chain reaction-restriction fragment length polymorphism assay. The VEGF -2578AA genotype was associated with an increased prevalence (≥4) of RIF [adjusted odds ratio (AOR)=2.77; 95% confidence interval (CI)=1.10-7.02; P=0.031], whereas the VEGF -634CG+GG genotype was associated with an increased incidence of total RIF (AOR=2.03; 95% CI=1.02-4.05; P=0.044) and ≥4 RIF (AOR=3.16; 95% CI=1.19-8.37; P=0.021). The results of the haplotype analysis indicated that -2578A/-1154A/-634G/936C (AOR=1.76; 95% CI=1.03-3.00; P=0.040 for total RIF and AOR=2.11; 95% CI=1.12-3.97; P=0.021 for ≥4 RIF) was associated with the occurrence of RIF. In addition, it was revealed that there was a significant difference in serum prolactin level associated with the VEGF -634C>G polymorphism (P=0.013). Therefore the findings of the present study indicate that the VEGF -2578AA genotype, -634G allele and -2578A/-1154A/-634G/936C haplotype may be genetic markers for susceptibility to RIF. However, further studies on VEGF promoter polymorphisms that include an independent randomized-controlled population are required to confirm these results.

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Section: Introductionmentioning

confidence: 99%

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

et al. 2017

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“…Correlations between VEGF +936C/T and -634C/G gene polymorphisms and PE have been widely studied [17][18][19][20][21][22][23][24][25], but the conclusions of studies in different regions are inconsistent. Some studies had a small sample size (N≤100) [28,[40][41][42], which may have affected the accuracy of the results.…”

Section: Resultsmentioning

confidence: 99%

“…In reports of the relationship between the VEGF + 936C/T and − 634G/C polymorphisms and PE susceptibility [17][18][19][20][21][22][23][24][25][26][40][41][42], some reports indicated that the + 936C/T polymorphism was related to the risk of PE [17,[20][21][22], while other studies reported that the + 936C/T polymorphism was not associated with PE risk [18,19,23,24]. Similarly, regarding the relationship between the − 634G/C polymorphism and PE susceptibility, most of the results were negative [19,24,25], but there are also reports that this polymorphism is associated with severe PE [16]. Analysis of the possible factors affecting the results and speculation that certain clinical factors (such as the differences in the study area and population included in the study, the sample size, and the inclusion and exclusion criteria for the study group) may cause bias, resulting in false negative or false positive results.…”

Section: Discussionmentioning

confidence: 99%

“…The VEGF + 936C/T and − 634C/G mutation sites have been shown to further affect the development of the disease by changing the transcription level and protein expression of VEGF [14][15][16]. There are many reports on the relationship between VEGF + 936C/T and − 634C/G and PE susceptibility [17][18][19][20][21][22][23][24][25]. However, the results are inconsistent across regions.…”

Section: Introductionmentioning

confidence: 99%

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Vascular endothelial growth factor +936C/T and -634G/C polymorphisms exhibited significantly different allelic distributions and no associations with the risk of preeclampsia, gestational hypertension or gestational diabetes mellitus in the Xinjiang Uygur Autonomous Region of China

Chen

Xue

Ding

et al. 2020

Preprint

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Background: The relationships between vascular endothelial growth factor (VEGF) + 936C/T and − 634C/G gene polymorphisms and certain diseases have been widely reported. According to reported data, there may be geographical and/or ethnic differences in VEGF + 936C/T and − 634C/G allele frequencies. Xinjiang is a multi-ethnic region in China in which the distributions of the + 936C/T and − 634C/G allele frequencies in various ethnic groups and their correlations with common complications during pregnancy (preeclampsia (PE), gestational hypertension (GH) and gestational diabetes mellitus (GDM)) have not been studied. Methods: A total of 2161 women (1551 controls with normal pregnancy, 232 patients with PE, 59 patients with GH and 319 patients with GDM) were recruited for this study. Sanger sequencing was used to screen VEGF + 936C/T and − 634C/G genotypes. The Pearson chi-square test was used to test the associations between diseases and + 936C/T and − 634C/G polymorphisms. Results: We investigated the distributions of VEGF + 936C/T and − 634G/C allele frequencies in healthy pregnant women in different regions of the world and found significant differences. Our data showed that the distributions of + 936C/T and − 634G/C allele frequencies between healthy Han and Uygur women in the Xinjiang area were significantly different. We found that VEGF + 936C/T and − 634G/C gene polymorphisms were not correlated with mild PE (mPE), severe PE (sPE), GH or GDM. Ethnic subgroup analysis revealed that the + 936C/T and − 634G/C gene polymorphisms in the Han, Uygur and Hui populations were also not related to PE, GH or GDM. Conclusions: The results showed that VEGF + 936C/T and − 634G/C gene polymorphisms had significant regional and ethnic distribution differences. In Xinjiang, VEGF + 936C/T and − 634G/C gene polymorphisms do not confer susceptibility to PE, GH or GDM.

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“…Consistent with this hypothesis, some circulating markers have been associated with both pregnancy loss and preeclampsia (e.g., PAPP-A [3][4][5][6]; sFlt-1, PlGF [7,8]). Furthermore, genetic polymorphisms in certain genes have been associated with both conditions (e.g., VEGF [9][10][11][12]; PAPP-A [13,14]; TNF-α [15,16]), potentially suggesting a common genetic susceptibility. Endothelial dysfunction has been proposed as a mechanism that might underlie these shared risks [17].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy complications recur independently of maternal vascular malperfusion lesions

Christians

Muñoz

2020

PLoS ONE

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Background Spontaneous abortions, intrauterine growth restriction, and preeclampsia are thought to be caused by defective placentation and are associated with increased risk of adverse outcomes in subsequent pregnancies. However, it is not known whether the recurrence of adverse outcomes is associated with the recurrence of placental pathology. We hypothesized that recurrent maternal vascular malperfusion (MVM) underlies the recurrence of adverse outcomes.

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Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia: A case-control study

Cited by 14 publications

References 31 publications

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

Vascular endothelial growth factor +936C/T and -634G/C polymorphisms exhibited significantly different allelic distributions and no associations with the risk of preeclampsia, gestational hypertension or gestational diabetes mellitus in the Xinjiang Uygur Autonomous Region of China

Pregnancy complications recur independently of maternal vascular malperfusion lesions

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