Vascular Endothelial Growth Factor (VEGF) System Expression in Human Fallopian Tube With Ectopic Pregnancy

Huang, Huei-Jean; Wu, Jiashin; Chan, S.L.I.; Wang, H.; Wang, C.; Soong, Yung Kuei

doi:10.1016/j.fertnstert.2005.07.1140

Cited by 1 publication

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“…They later showed a good and specific tumour to background ratio in a preclinical model for both the 99m Tc and the 64 Cu-labelled scVEGF, even though a high degree of heterogeneity was noticed [ 27 ]. Aiming for imaging at a later time point, Chan et al developed a recombinant protein composed of VEGF165 fused through a flexible polypeptide linker to the n-lobe of human transferrin (hnTf), thus allowing labelling without the introduction of a specific chelator [ 105 ]. Although showing a reasonable tumour to background ratio, this tracer was found to be insufficiently stable in vivo.…”

Section: Direct Targeting Of Angiogenesismentioning

confidence: 99%

Molecular Imaging of Angiogenesis in Oncology: Current Preclinical and Clinical Status

Florea

Mottaghy

Bauwens

2021

IJMS

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Angiogenesis is an active process, regulating new vessel growth, and is crucial for the survival and growth of tumours next to other complex factors in the tumour microenvironment. We present possible molecular imaging approaches for tumour vascularisation and vitality, focusing on radiopharmaceuticals (tracers). Molecular imaging in general has become an integrated part of cancer therapy, by bringing relevant insights on tumour angiogenic status. After a structured PubMed search, the resulting publication list was screened for oncology related publications in animals and humans, disregarding any cardiovascular findings. The tracers identified can be subdivided into direct targeting of angiogenesis (i.e., vascular endothelial growth factor, laminin, and fibronectin) and indirect targeting (i.e., glucose metabolism, hypoxia, and matrix metallo-proteases, PSMA). Presenting pre-clinical and clinical data of most tracers proposed in the literature, the indirect targeting agents are not 1:1 correlated with angiogenesis factors but do have a strong prognostic power in a clinical setting, while direct targeting agents show most potential and specificity for assessing tumour vascularisation and vitality. Within the direct agents, the combination of multiple targeting tracers into one agent (multimers) seems most promising. This review demonstrates the present clinical applicability of indirect agents, but also the need for more extensive research in the field of direct targeting of angiogenesis in oncology. Although there is currently no direct tracer that can be singled out, the RGD tracer family seems to show the highest potential therefore we expect one of them to enter the clinical routine.

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Section: Direct Targeting Of Angiogenesismentioning

confidence: 99%