Vascular endothelial growth factor (VEGF) expression in dogs suffering from squamous cell carcinoma

Sobczyńska-Rak, Aleksandra; Polkowska, Izabela; Gołyńska, Magdalena; Szponder, Tomasz; Żylińska, Beata; Łopuszyński, Wojciech

doi:10.21521/mw.5693

Cited by 1 publication

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SCCs are described in the veterinary literature as a common neoplasia of the cranium, especially in cats, along with mast cell tumors and soft tissue sarcomas [ 4 , 5 ]. Cutaneous SCC tends to proliferate in the dermis and subcutaneous tissue and show local aggressiveness and infrequent distant metastases; however, in the advanced stages, mild to moderate bone involvement is possible [ 1 , 2 , 5 , 19 ]. In people, SCC of the skull has been described as an infiltrating lesion causing adjacent bone destruction but without a tendency to be extensive, especially in cases of papillary SCC and in the upper respiratory tract, for which it constitutes 70–90% of all head malignant lesions [ 19 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…In animals, the possibility of the local aggressiveness of SCCs has been mentioned only in a few reports [ 2 , 25 ]. Tomographic findings include the presence of neoplastic tissue with areas of mineralization and variable osteolysis of adjacent bone [ 5 , 8 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Squamous cell carcinoma (SCC) is a malignant neoplasia originating from squamous epithelium [ 1 , 2 ]. In dogs, it accounts for approximately 5% of all skin tumors, while in people, it accounts for 20% of skin malignancies [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Ultraviolet light as well as ionizing radiation, exposure to chemical carcinogens, long-standing dermatoses, scars and other chronic lesions are important predisposing factors [2,[9][10][11]. Recently, the papilloma viruses have been mentioned as potential factors involved in SCC etiology as well [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…The disease manifestation in animals is similar to that in humans and differs depending on the SCC malignancy grade and location. SCC is mainly locally aggressive and shows rapid growth, but lymph node and distant metastasis are rare [1][2][3]. An exception is SCC located in the palatine tonsils, for which micrometastases are often found in regional lymph nodes as well as in the lungs when the primary tumor is diagnosed [15].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Aggressive squamous cell carcinoma of the cranium of a dog

Łojszczyk-Szczepaniak

Łopuszyński

Szadkowski

et al. 2021

BMC Vet Res

Self Cite

View full text Add to dashboard Cite

Background The authors report a case of keratinized squamous cell carcinoma (SCC) in a 14-year-old dog with extensive cranial bone invasion. To our knowledge, this is the first description of such a case of cranial keratinized SCC with aggressive generalized osteolysis described in a dog. Case presentation The 14-year-old dog was referred for radiological examination with suspicion of head trauma with clinical signs of head deformation, exophthalmos and nasal discharge. The skull radiographs showed a large osteolytic defect of the frontal bone and parietal bone in the region of the external sagittal crest. Findings from the skull CT scan included generalized osteolysis in the region of parietal bone, frontal bones, maxilla on the right side and the nasal bone including the dorsal nasal concha. In the area of bone loss, new soft tissue formation with multifocal foci of mineralization was visible. The ultrasound examination revealed hypoechogenic changes with hyperechoic foci consistent with mineralization and poor vascularization. The brain and ocular structures were without visible changes. Fine needle aspiration cytology (FNAC) was performed, and squamous cell carcinoma was suspected. After 3 months, the re-presented to the clinic. The dog became progressively listless, his appetite was decreased, and he became acutely blind. Follow-up skull CT scan revealed significant osteolysis, which affected a significant aspect of the cranium. All bone defects had been replaced by new 3.5 cm-thick soft tissue formations with multifocal small 1–2 mm areas of mineralization. There was no evidence of metastasis. Histological examination confirmed the suspicion of squamous cell carcinoma. Conclusions This paper is the first report of cranial SCC in a dog causing extensive bone osteolysis. The lesions in this dog originated from the frontal and parietal bones including frontal sinuses. There are variants of tumors that arise from squamous epithelium or resemble SCC in the skull. These examples include adenosquamous carcinoma and proliferating trichilemmal tumours. In addition, there is possible malignant transformation caused by papilloma viruses. In the veterinary literature, there is only one similar description of adenosquamous carcinoma in a cat with similar clinical manifestations. It is justified to suspect a process of neoplastic epithelial origin in all cases of aggressive and extensive skull bone lysis. This issue should be subject to further investigation.

show abstract