Vascular endothelium growth factor and angiogenin in the serum of patients with osteosarcoma and Ewing’s tumor

Abstract

The concentrations of vascular endothelium growth factor and angiogenin were measured by enzyme immunoassay in the sera of healthy subjects and patients with osteosarcoma and Ewing's tumor with consideration for the main clinical and morphological characteristics of the diseases. The studied angiogenic factors were characterized by high individual variability in both healthy subjects and age- and sex-matched patients with primary bone sarcomas. The level of endothelial growth factor was higher in control women than in men. The highest concentration of endothelial growth factor was detected in male patients with Ewing's tumor. Possible involvement of vascular endothelium growth factor and angiogenin in the pathogenesis of osteosarcoma and Ewing's tumor is discussed.

A therapeutic target for prostate cancer based on angiogenin-stimulated angiogenesis and cancer cell proliferation

“…Although angiogenin expression is elevated in many types of human cancer (2)(3)(4)(5)(6)(7)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), nuclear angiogenin has so far only been reported in breast cancer tissue samples (27). The strong nuclear angiogenin staining in prostate cancer samples (Fig.…”

“…Its expression is up-regulated in various types of human cancers, including breast (2), cervical (3), colon (4), colorectal (5), endometrial (6), gastric (7), liver (8), kidney (9), ovarian (10), pancreatic (11), prostate (12), and urothelial (13) cancers, as well as astrocytoma (14), leukemia (acute myeloid leukemia and myelodysplastic syndrome) (15,16), lymphoma (non-Hodgkin's) (17), melanoma (18), osteosarcoma (19), and Wilms' tumor (20). Among them, prostate cancer, in which angiogenin expression is positively correlated with disease progression (12), is of particular interest.…”

Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis

“…It has been shown to play a role in tumor angiogenesis (Olson et al, 1995(Olson et al, , 2001(Olson et al, , 2002. Its expression increases in a variety of cancer cells, which results in an elevation of plasma angiogenin in cancer patients (Li et al, 1994;Barton et al, 1997;Montero et al, 1998;Shimoyama et al, 1999;Eberle et al, 2000;Kushlinskii et al, 2000;Bodner-Adler et al, 2001;Ugurel et al, 2001;Homer et al, 2002;Shimoyama et al, 2002). Angiogenin antagonists have been shown to inhibit the establishment, progression, and metastasis of xenografic human tumors in athymic mice (Olson et al, 1995(Olson et al, , 2001(Olson et al, , 2002.…”

A New Concept for Androgen Receptor-Independent Growth of Prostate Cancer

“…tumor therapy ͉ nuclear translocation ͉ ribosome biogenesis A ngiogenin is a 14-kDa angiogenic ribonuclease originally isolated from HT-29 colon adenocarcinoma cells (1). Its expression is up-regulated in various types of human cancers, including breast (2), cervical (3), colon (4), colorectal (5), endometrial (6), gastric (7), liver (8), kidney (9), ovarian (10), pancreatic (11), prostate (12), and urothelial (13) cancers, as well as astrocytoma (14), leukemia (acute myeloid leukemia and myelodysplastic syndrome) (15,16), lymphoma (non-Hodgkin's) (17), melanoma (18), osteosarcoma (19), and Wilms' tumor (20). Among them, prostate cancer, in which angiogenin expression is positively correlated with disease progression (12), is of particular interest.…”