2023
DOI: 10.1038/s41420-023-01443-9
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Vascular endothelium is the basic way for stem cells to treat erectile dysfunction: a bibliometric study

Abstract: Vascular endothelial is considered to be a key factor in the pathogenesis of erectile dysfunction (ED). The purpose is to reveal the research trend of the field of ED and vascular endothelium. In addition, the goal is to discover the role and mechanism of vascular endothelium in ED. Bibliometrics and visualization methods based on CiteSpace were selected. We conducted the co-authorship analysis of countries, institutions and authors, co-occurrence analysis of keywords, and co-citation analysis of literature an… Show more

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Cited by 6 publications
(2 citation statements)
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“…ED is a complex disorder primarily caused by reduced nitric oxide formation due to impaired neural and endothelial function of the corpus cavernosum of the penis [ 22 ]. However, there are other pathophysiological mechanisms, such as high blood pressure, androgen deficiency, arteriosclerosis, high cholesterol levels, diabetes mellitus, prostate diseases, and anatomical deformation of the penis [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…ED is a complex disorder primarily caused by reduced nitric oxide formation due to impaired neural and endothelial function of the corpus cavernosum of the penis [ 22 ]. However, there are other pathophysiological mechanisms, such as high blood pressure, androgen deficiency, arteriosclerosis, high cholesterol levels, diabetes mellitus, prostate diseases, and anatomical deformation of the penis [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…More than half of men with DM have erectile dysfunction (ED) worldwide, with a prevalence 3.5‐fold times higher than those without DM [ 159 ]. Diabetic erectile dysfunction (DED) involves multiple pathogenesis, such as the dysregulation of VEGF signaling transduction due to hyperglycemia, elevated levels of advanced glycation end products (AGEs), the synthesis of nitric oxide synthase (NOS), heightened production of oxygen free radicals in neurons, and reduced NO and cyclic guanosine monophosphate (cGMP)-dependent protein kinase-1 (cGKI) [ 160 ]. The deleterious effects of hyperglycemia and endothelial dysfunction of the vascular lining caused by oxidative stress is the basic pathophysiology of DED.…”
Section: Mscs Derived Exosomes and Diabetic Complicationsmentioning
confidence: 99%