Vascular Extracellular Superoxide Dismutase Activity in Patients With Coronary Artery Disease

Abstract

In patients with CAD, vascular EC-SOD activity is substantially reduced. The close relation between endothelium-bound EC-SOD activity and FDD suggests that reduced EC-SOD activity contributes to endothelial dysfunction in patients with CAD. In young hypercholesterolemic individuals, however, endothelium-bound EC-SOD activity is increased and may, in part, counteract impairment of endothelial function as the result of increased formation of oxygen free radicals.

Olmesartan improves endothelial function in hypertensive patients: link with extracellular superoxide dismutase

“…34 EC-SOD is anchored to heparan sulfate proteoglycans on endothelial cells and released by treatment with heparin in vitro and in vivo. Landmesser et al 35 reported that heparin-releasable (that is, endothelium-bound) EC-SOD activity was substantially reduced in patients Olmesartan improves endothelial function S Takiguchi et al with coronary artery disease, as well as a close relationship between endothelium-bound EC-SOD activity and endothelial function. They also demonstrated that ACEI and ARB improved endothelial function in the radial artery by increasing endothelium-bound EC-SOD activity.…”

Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival

“…18,35 Vascular Ec-SOD activity correlated with the endothelium dependent vasodilatation and is low in patients with a history of myocardial infarction and coronary artery disease. 6 Restoration of Ec-SOD availability is associated with improvement of endothelial function in patients with CAD and is related to reduction of oxidative stress in vessel wall. 5 Earlier studies carried out in rats have shown that infusion of recombinant Ec-SOD protein resulted in reduced levels of creatine kinase in the left ventricular free wall and SOD bound to endothelial surface was also associated with lower cardiac damage in Langendorffperfused rat hearts subject to 15 min of global ischemia followed by reperfusion.…”

“…4 A number of recent clinical studies have reported reduced levels of human extracellular superoxide dismutase (Ec-SOD) in patients with coronary artery disease and myocardial infarction. [5][6][7] Superoxide anion is product of oxygen metabolism and is produced by activated inflammatory cells. [8][9][10] SODs are family of metalloproteins that scavenges superoxide anion radicals and form oxygen and hydrogen peroxide.…”

Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training

“…Indeed, in Apo (E)-deficient mice, we have previously found that the vascular smooth muscle cell expression of ecSOD declines as the severity of atherosclerosis increases (15). Landmesser et al have recently shown that plasma levels of ecSOD are markedly reduced in individuals with advanced atherosclerosis (51). One explanation for these findings is that atherosclerosis is associated with a loss of endothelium-derived NO production and/or bioreactivity, leading to a decrease in ecSOD expression.…”