Vascular Findings in the Stria Vascularis of Patients With Unilateral or Bilateral Ménière's Disease

Kariya, Shin; Cüreoğlu, Sebahattin; Fukushima, Hisaki; Nomiya, Shigenobu; Nomiya, Rie; Schachern, Patricia A.; Nishizaki, Kazunori; Paparella, Michael M.

doi:10.1097/mao.0b013e3181b4ec89

Cited by 31 publications

(21 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Circulatory disturbances affecting both temporal bones have been proposed in more detailed studies of patients with unilateral MD. The abnormalities found in the stria vascularis of the asymptomatic ear were related to a significant reduction in the number of vessels, which was similar both in the symptomatic and asymptomatic or contralateral ear [Kariya et al, 2009].…”

Section: Discussionmentioning

confidence: 72%

Auditory and Vestibular Assessment of Patients with Ménière’s Disease Who Suffer Tumarkin Attacks

et al. 2010

View full text Add to dashboard Cite

Tumarkin attacks are a feature of Ménière’s disease that generate a significant degree of disability. The surprising nature of these events is the main reason behind their associated morbidity. In this study we set out to evaluate auditory and vestibular function, as well as disability, in a population of patients who suffer Tumarkin attacks. We found that patients who suffer Tumarkin attacks are more disabled and experience severer and more frequent autonomic symptoms and that their hearing level is significantly worse in the asymptomatic ear, especially at low frequencies. Accordingly, we consider that treatment must be carefully planned to be as conservative as possible in terms of hearing and that psychiatric and/or psychological treatment must always be considered as an adjuvant therapy.

show abstract

Section: Discussionmentioning

confidence: 72%

Auditory and Vestibular Assessment of Patients with Ménière’s Disease Who Suffer Tumarkin Attacks

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Thus, regulation of fluid homeostasis by the SV is assumed to be highly dependent on circulating GCs. In Ménière's disease, the SV is known to be severely atrophic and shows degeneration (26). In such pathologic condition, fluid regulation in the SV by GCs is assumed to be disturbed, and the clinical efficacy of GCs for Ménière's disease may well be diminished.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Glucocorticoid Receptors and 11β-Hydroxysteroid Dehydrogenase Isoforms in the Human Inner Ear

Kumagami

Terakado

Takahashi

2013

Otology &Amp; Neurotology

View full text Add to dashboard Cite

show abstract

“…Another recent cohort study showed that chronic inflammation and immune dysregulation, the characteristics of SLE, induce a high incidence of atherosclerotic vascular events and accelerated cardiovascular disease (21). The stria vascularis requires a high level of blood supply to maintain the endocochlear potential levels and that the impaired homeostasis of the cochlear blood supply due to arteriosclerosis results in degeneration of the stria vascularis (22, 23). A human temporal bone study by Nomiya et al showed that patients with arteriosclerosis had a decreased number of cochlear hair cells, as compared with normal controls (24).…”

Section: Discussionmentioning

confidence: 99%

Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus

Kariya¹,

Kaya

Hızlı

et al. 2016

Otology &Amp; Neurotology

Self Cite

View full text Add to dashboard Cite

Hypothesis We hypothesized that, in archived human temporal bone samples from patients with systemic lupus erythematosus (SLE), a pathologic condition exists in the stria vascularis and cochlear hair cells. Background Sensorineural hearing loss is a common feature in SLE patients. However, the pathophysiologic mechanism of cochlear dysfunction is unclear. Methods We examined 15 temporal bone samples from 8 SLE patients, along with 17 samples from 10 age-matched healthy control patients. The samples were serially sectioned in the horizontal plane and stained with hematoxylin and eosin. We determined the area of the stria vascularis in a midmodiolar section of each cochlear turn. Then, we made cytocochleograms and calculated the percentage of missing inner and outer hair cells. Results The area of the stria vascularis in our SLE group was significantly smaller than in our control group. The number of remaining inner hair cells in our SLE group was smaller than in our control group; however, the difference did not reach statistical significance. The loss of outer hair cells in our SLE group was significantly higher than in our control group. There was a tendency toward a positive correlation between the loss of cochlear hair cells and the duration of SLE. Conclusion The stria vascularis and cochlear hair cells are affected in SLE patients. Our findings could provide the histopathologic basis for the cochlear dysfunction, including sensorineural hearing loss, experienced by SLE patients.

show abstract

Vascular Findings in the Stria Vascularis of Patients With Unilateral or Bilateral Ménière's Disease

Abstract: The stria vascularis may be ischemic bilaterally both in bilateral and unilateral Ménière's disease. Abnormal findings in the contralateral ears in unilateral Ménière's disease reported in previous studies might be related to poor vascularity of the stria vascularis.

Cited by 31 publications

References 23 publications

Auditory and Vestibular Assessment of Patients with Ménière’s Disease Who Suffer Tumarkin Attacks

Auditory and Vestibular Assessment of Patients with Ménière’s Disease Who Suffer Tumarkin Attacks

Distribution of Glucocorticoid Receptors and 11β-Hydroxysteroid Dehydrogenase Isoforms in the Human Inner Ear

Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus

Contact Info

Product

Resources

About