Vascular flow reserve as a link between long-term blood pressure level and physical performance capacity in mammals

Poulsen, Christian Bo; Damkjær, Mads; Hald, Bjørn Olav; Wang, Tobias; Holstein‐Rathlou, Niels‐Henrik; Jacobsen, Jens Christian Brings

doi:10.14814/phy2.12813

Cited by 2 publications

(1 citation statement)

References 61 publications

(103 reference statements)

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“…A plethora of comparative studies shows that cardiac output ( Q ) scales proportionally to the higher mass‐specific metabolism of small animals by virtue of increased heart rate ( f H ), while stroke volume (Vs) constitutes a constant proportion of body mass . Most authors note that MAP is unaffected by body mass, such that peripheral vascular resistance decreases proportionally to mass‐specific metabolism. Others have argued that MAP does indeed increase with body mass in mammals, albeit with a substantially smaller scaling exponent than f H (eg Ref.…”

Section: Introductionmentioning

confidence: 99%

Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure

et al. 2017

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For at least the last 30 years, it has been discussed whether mean arterial blood pressure (MAP) is independent of body mass or whether it increases in accordance with the vertical height between the heart and the brain. The debate has centred on the most appropriate mathematical models for analysing allometric scaling and phylogenetic relationships; there has been previously little focus on evaluating the validity of underlying physiological data. Currently, the 2 most comprehensive scaling analyses are based on data from 47 species of mammals, based on 114 references. We reviewed all available references to determine under which physiological conditions MAP had been recorded. In 44 (38.6%) of the cited references, MAP was measured in anaesthetized animals. Data from conscious animals were reported in 59 (51.8%) of references; of these, 3 (2.6%) were radiotelemetric studies. In 5 species, data were reported from both anaesthetized and conscious animals, and the mean difference in the MAP between these settings was 20 ± 29 mm Hg. From a literature search, we identified MAP measurements performed by radiotelemetry in 11 of the 47 species included in the meta-analyses. A Bland-Altman analysis showed a bias of 1 mm Hg with 95% confidence interval (from -35 to 36 mm Hg); that is, the limits of agreement between radiotelemetric studies and studies in restrained animals were double the supposed difference in the MAP between the mouse and elephant. In conclusion, the existing literature does not provide evidence for either a positive or neutral scaling of arterial pressure to body mass across taxa.

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Section: Introductionmentioning

confidence: 99%

Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure

et al. 2017

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Lack of tone in mouse small mesenteric arteries leads to outward remodeling, which can be prevented by prolonged agonist-induced vasoconstriction

Klein

Joseph

Christensen

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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Inward remodeling of resistance vessels is an independent risk factor for cardiovascular events. Thus far, the remodeling process remains incompletely elucidated, but the activation level of the vascular smooth muscle cell appears to play a central role. Accordingly, previous data have suggested that an antagonistic and supposedly beneficial response, outward remodeling, may follow prolonged vasodilatation. The present study aimed to determine whether 1) outward remodeling follows 3 days of vessel culture without tone, 2) a similar response can be elicited in a much shorter 4-h timeframe, and, finally, 3) whether a 4-h response can be prevented or reversed by the presence of vasoconstrictors in the medium. Cannulated mouse small mesenteric arteries were organocultured for 3 days in the absence of tone, leading to outward remodeling that continued throughout the culture period. In more acute experiments in which cannulated small mesenteric arteries were maintained in physiological saline without tone for 4 h, we detected a similar outward remodeling that proceeded at a rate several times faster. In the 4-h experimental setting, continuous vasoconstriction to ~50% tone by abluminal application of UTP or norepinephrine + neuropeptide Y prevented outward remodeling but did not cause inward remodeling. Computational modeling was used to simulate and interpret these findings and to derive time constants of the remodeling processes. It is suggested that depriving resistance arteries of activation will lead to eutrophic outward remodeling, which can be prevented by vascular smooth muscle cell activation induced by prolonged vasoconstrictor exposure. NEW & NOTEWORTHY We have established an effective 4-h method for studying outward remodeling in pressurized mouse resistance vessels ex vivo and have determined conditions that block the remodeling response. This allows for investigating the subtle but clinically highly relevant phenomenon of outward remodeling while avoiding both laborious 3-day organoid culture of cannulated vessels and in vivo experiments lasting several weeks.

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Vascular flow reserve as a link between long-term blood pressure level and physical performance capacity in mammals

Cited by 2 publications

References 61 publications

Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure

Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure

Lack of tone in mouse small mesenteric arteries leads to outward remodeling, which can be prevented by prolonged agonist-induced vasoconstriction

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