Vascular function and cognition in persons with multiple sclerosis: Preliminary examination

Zheng, Peixuan; Pilutti, Lara A.; DuBose, Noah G.; Motl, Robert W.

doi:10.1016/j.msard.2023.104578

Cited by 8 publications

(1 citation statement)

References 52 publications

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“…cytokines circulating in blood) might directly influence arterial remodeling, resulting in increased arterial stiffness in MS. 8 The further examination of the aforementioned underlying pathophysiological processes and others (e.g. oxidative stress, sex hormones, and renin–angiotensin–aldosterone system) is important for identifying interventions for reducing arterial stiffness in MS, and markers of arterial stiffness (cfPWV and PP) have been associated with outcomes, such as cognitive and walking function in persons with MS 9,10 as well as cardiovascular morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Arterial stiffness in persons with multiple sclerosis and controls: Does aerobic fitness account for group differences?

DeJonge,

DuBose,

Pilutti

et al. 2023

Mult Scler

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Vascular function is worse in multiple sclerosis (MS) than healthy controls perhaps based on differences in aerobic fitness. We compared carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx75) between MS and controls while accounting for aerobic fitness. Aerobic fitness was measured as peak oxygen consumption on a recumbent stepper. cfPWV and AIx75 were measured using applanation tonometry. Persons with MS demonstrated lower aerobic fitness and higher cfPWV, but no difference in AIx75 compared with controls. The difference in cfPWV remained statistically significant after controlling for aerobic fitness, suggesting that arterial stiffness might reflect underlying pathophysiology processes of MS.

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Section: Discussionmentioning

confidence: 99%