Vascular Graft Infection by Staphylococcus aureus: Efficacy of Cefazolin, Teicoplanin and Vancomycin Prophylaxis Protocols in a Rat Model

Atahan, Erhan; Gül, Mustafa; Ergün, Yusuf; Eroğlu, Erdinç

doi:10.1016/j.ejvs.2007.03.002

Cited by 20 publications

(23 citation statements)

References 35 publications

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“…Reports from the basic science literature describe polymers capable of releasing varied antibiotics such as cefazolin and vancomycin [5,[26][27][28]. These studies generally have a maximum follow-up period of 14 d and use primarily diffusion-based drug delivery polymers.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic-Releasing Mesh Coating to Reduce Prosthetic Sepsis: An In Vivo Study

Harth

Rosen

Thatiparti

et al. 2010

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Antibiotic-Releasing Mesh Coating to Reduce Prosthetic Sepsis: An In Vivo Study

Harth

Rosen

Thatiparti

et al. 2010

Journal of Surgical Research

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“…[1][2][3][4] Classic management of this challenging problem includes complete removal of a prosthetic implant with extra-anatomic reconstruction. 5 Other management strategies have included selected in situ replacement or graft preservation.…”

mentioning

confidence: 99%

Antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary vascular surgical site infections

Stone

Mousa

Hass

et al. 2012

Journal of Vascular Surgery

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Antibiotic-loaded PMMA beads may serve as an adjunct in the management of VSSIs and may also expand treatment options for graft preservation or in situ reconstruction, with expected recurrent infection rate approaching 20%. Further experience with this adjunct may help elucidate its role in the management of this complicated problem, including the need for bead exchanges, until perigraft cultures are free of microbes.

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“…40,41 Teicoplanin has a similar antibacterial spectrum similar to that of vancomycin, but a longer half-life and a lower risk of serious side effects. 42−46 Atahan et al 47 reported that teicoplanin shows superior effects in vascular graft infection with MSSA and MRSA compared to vancomycin.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of moxifloxacin compared to teicoplanin in the treatment of implant‐related chronic osteomyelitis in rats

Özturan

Yücel

Koçoğlu

et al. 2010

Journal Orthopaedic Research

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Treatment of implant-related chronic osteomyelitis is often difficult and usually consists of implant removal, extensive surgical debridement, and prolonged antibiotic use. This study was performed to assess the efficacy of moxifloxacin compared to a glycopeptide, teicoplanin in chronic implant-related methicillin-sensitive Staphylococcus aureus (MSSA) osteomyelitis. The left femoral medullar cavities of 60 Wistar male rats were contaminated with 100 l of 10 8 cfu/ml methicillin-sensitive S. aureus (ATCC 29213) and Kirschner wires were placed into the medulla of the femur. After 6 weeks, rats were randomly divided into five groups. In two groups, the Kirschner wires were removed. Experimental groups were as follows: group 1: contaminated, Kirschner wire inside, received teicoplanin; group 2: contaminated, Kirschner wire removed, received teicoplanin; group 3: contaminated, Kirschner wire inside, received moxifloxacin; group 4: contaminated, Kirschner wire removed, received moxifloxacin; group 5: contaminated, Kirschner wire inside, no antibiotics (control group). Groups 1 and 2 received teicoplanin (20 mg/kg once daily), whereas groups 3 and 4 received moxifloxacin (10 mg/kg twice daily) intraperitoneally for 28 days. At the end of the treatment, animals were sacrificed by inhalation anesthesia with ether and femora were retrieved and bacterial counts (cfu/g) were determined. Bacterial counts in all study groups were significantly reduced relative to the control. The decrease of bacterial counts was more prominent in group 4 compared to group 1 (p = 0.001) and group 2 (p = 0.003). Moxifloxacin therapy is an effective alternative to teicoplanin for chronic implant-related MSSA osteomyelitis.

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Vascular Graft Infection by Staphylococcus aureus: Efficacy of Cefazolin, Teicoplanin and Vancomycin Prophylaxis Protocols in a Rat Model

Abstract: As a prophylactic agent, teicoplanin seems to be more effective than vancomycin and cefazolin against vascular graft infections caused by MSSA and MRSA in rats.

Cited by 20 publications

References 35 publications

Antibiotic-Releasing Mesh Coating to Reduce Prosthetic Sepsis: An In Vivo Study

Antibiotic-Releasing Mesh Coating to Reduce Prosthetic Sepsis: An In Vivo Study

Antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary vascular surgical site infections

Efficacy of moxifloxacin compared to teicoplanin in the treatment of implant‐related chronic osteomyelitis in rats

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