Vascular iliac myofascial flap to repair compound defect of the jaw

Wu, Luping; Wang, Xinmiao; Liu, Ke; Shang, Zhengjun; Wu, Tianfu; Shao, Zhang

doi:10.1016/j.jormas.2022.06.022

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…These attributes contribute to the widespread preference for vascularized iliac aps in jaw repair procedures. [1][2][3] Nonetheless, a recent meta-analysis indicated that roughly 7% of patients undergoing mandibular reconstruction with vascularized iliac crest aps experience ap failure. [4] While this percentage might seem small, ap loss can in ict signi cant consequences, from compromised function and aesthetics to nancial strain.…”

Section: Introductionmentioning

confidence: 99%

D-dimer-based prediction model for flap loss in iliac bone transplantation

Wu,

Zhou,

et al. 2024

Preprint

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Background: In recent years, the utilization of autogenous vascularized iliac crest flap for repairing jaw defects has seen a significant rise. However, the visual monitoring of iliac bone grafts presents challenges, frequently leading to delayed detection of flap necrosis. Consequently, there's a pressing need to devise effective indicators for monitoring postoperative complications in iliac crest flaps. Methods: A retrospective review was conducted on 160 patients who underwent vascularized iliac bone transplantation surgery in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, China, between January 2020 and December 2022. Results On the first day following surgery, patients who experienced thrombosis exhibited a substantial increase in plasma D-dimer levels, reaching 3.75 mg/L, a Fig. 13.84 times higher than the baseline. This difference was statistically significant (P < 0.05) compared to patients without postoperative complications. Furthermore, the nomogram we have developed and validated effectively predicts venous thrombosis, assigning individual risk scores to patients. This predictive tool was assessed in both training and validation cohorts, achieving areas under the curve (AUC) of 0.630 and 0.600, with the 95% confidence intervals of 0.452–0.807 and 0.243–0.957, respectively. Conclusions: Our study illustrates that postoperative plasma D-dimer levels can serve as a highly sensitive biomarker for monitoring thrombosis-induced flap loss. Moreover, we have developed a novel prediction model that integrates multiple factors, thereby enhancing the accuracy of early identification of patients at risk of thrombosis-associated flap loss. This advancement contributes to improving the overall management and outcomes of such procedures.

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Section: Introductionmentioning

confidence: 99%

D-dimer-based prediction model for flap loss in iliac bone transplantation

Wu,

Zhou,

et al. 2024

Preprint

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Vascularized fascial flap for reconstruction of combined oral mucosa-mandibular defects: The multi-modal biological assessment

Li,

AL-wesabi,

et al. 2024

Journal of Stomatology, Oral and Maxillofacial Surgery

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Multi-factor early monitoring method based on D-dimer for iliac crest flap loss

Wu,

Zhou,

et al. 2024

BMC Oral Health

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Background In recent years, the utilization of autogenous vascularized iliac crest flap for repairing jaw defects has seen a significant rise. However, the visual monitoring of iliac bone flaps present challenges, frequently leading to delayed detection of flap loss. Consequently, there’s a urgent need to develop effective indicators for monitoring postoperative complications in iliac crest flaps. Methods A retrospective analysis was conducted on 160 patients who underwent vascularized iliac crest flap transplantation for jawbone reconstruction from January 2020 to December 2022. We investigated the changes in D-dimer levels among patients with or without postoperative complications. Additionally, multivariable logistic regression analysis was performed to explore potential individual risk factors, including surgical duration, age, pathology type, absolute and relative D-dimer levels, and gender, culminating in the development of a nomogram. Results On the first day following surgery, patients who experienced thrombosis exhibited a substantial increase in plasma D-dimer levels, reaching 3.75 mg/L, 13.84 times higher than the baseline. This difference was statistically significant ( P < 0.05) compared to patients without postoperative complications. Furthermore, the nomogram we have developed and validated effectively predicts venous thrombosis, assigning individual risk scores to patients. This predictive tool was assessed in both training and validation cohorts, achieving areas under the curve (AUC) of 0.630 and 0.600, with the 95% confidence intervals of 0.452–0.807 and 0.243–0.957, respectively. Conclusions Our study illustrates that postoperative plasma D-dimer levels can serve as a sensitive biomarker for monitoring thrombosis-induced flap loss. Moreover, we have developed a novel prediction model that integrates multiple factors, thereby enhancing the accuracy of early identification of patients at risk of thrombosis-associated flap loss. This advancement contributes to improving the overall management and outcomes of such procedures. Supplementary Information The online version contains supplementary material available at 10.1186/s12903-024-04712-w.

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Vascular iliac myofascial flap to repair compound defect of the jaw

Cited by 3 publications

References 11 publications

D-dimer-based prediction model for flap loss in iliac bone transplantation

D-dimer-based prediction model for flap loss in iliac bone transplantation

Vascularized fascial flap for reconstruction of combined oral mucosa-mandibular defects: The multi-modal biological assessment

Multi-factor early monitoring method based on D-dimer for iliac crest flap loss

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