Vascular inflammation and impaired reverse cholesterol transport and lipid metabolism in obese children and adolescents

Martín, Maximiliano; Gaete, Laura; Tetzlaff, Walter Francisco; Ferraro, Florencia; Chiappe, Ezequiel Lozano; E, Eliana Botta; Osta, Viviana; Sáez, María Soledad Cruz; LorenzonGonzalez, Maria Victoria; Palenque, P.; Ballerini, Gabriela; Sorroche, Patricia; Boero, Laura; Triffone, Liliana; Brites, Fernando

doi:10.1016/j.numecd.2021.09.025

Cited by 12 publications

(9 citation statements)

References 69 publications

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“…(32,33) De hecho, en un trabajo previo, mostramos la asociación negativa que existe entre la presencia de inflamación específica vascular y el transporte inverso de colesterol en niños y adolescentes con obesidad. (34).…”

Section: Discussionunclassified

Diferencia en las distintas funciones de las lipoproteínas de alta densidad en respuesta a la infección por SARS-CoV-2

Davico,

Martín,

Lozano Chiappe

et al. 2024

Rev Argent Cardiol

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Introducción: El síndrome post COVID (SPC), que se caracteriza por síntomas que se extienden superando las 4 semanas post-infección, podría desencadenar aumento en el riesgo cardiovascular. Las lipoproteínas de alta densidad (HDL) presentan funciones antiaterogénicas, como su capacidad para promover el transporte inverso del colesterol (TIC) y su actividad antioxidante, en la que es clave la enzima paraoxonasa 1 (PON 1). Objetivo: Evaluar funcionalidad de HDL en pacientes con SPC comparados con pacientes asintomáticos (PA) y controles. Material y métodos: Se incluyeron 9 individuos con SPC, 18 PA y 10 controles. Se midieron el hemograma, el perfil lipoproteico básico, las apolipoproteínas A-I y B, y marcadores inflamatorios por métodos automatizados. La actividad de PON 1 se evaluó empleando un método espectrofotométrico y los 3 pasos del TIC, eflujo de colesterol (ECC), y actividades de lecitina:colesterol aciltransferasa (LCAT) y proteína transportadora de colesterol esterificado (CETP), por métodos radiométricos. Resultados: No se observaron diferencias en sexo, edad, ni parámetros generales. El grupo PA presentó mayor actividad PON que los controles (94±76 vs. 183±111 vs. 148±58 nmol/mL.min, en controles, PA y SPC, respectivamente; p=0,049). No se observaron diferencias en el TIC. El ECC (r=-0,45; p=0,049) y CETP (r=-0,38; p=0,028) correlacionaron negativamente con el índice neutrófilos/linfocitos. LCAT correlacionó inversamente con la ferritina (r=-0,34; p=0,046). Conclusiones: El incremento de PON 1 en el grupo PA representaría un mecanismo de defensa frente al estrés oxidativo postinfección. Todos los pasos del TIC mostraron una correlación negativa con marcadores inflamatorios. Nuestros resultados podrían explicar, en parte, el vínculo entre COVID y ateroesclerosis.

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Section: Discussionunclassified

Diferencia en las distintas funciones de las lipoproteínas de alta densidad en respuesta a la infección por SARS-CoV-2

Davico,

Martín,

Lozano Chiappe

et al. 2024

Rev Argent Cardiol

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“…Additionally, our findings indicate that Qatari adolescents have a higher prevalence of overweight and obesity when compared to other nationalities, a finding reported in a previous study [ 36 ]. Overweight and obesity among adolescents are a concerning public health problem as they increase the risk in this population of suffering from premature CVD [ 37 ]. Improving the walkability options in neighborhoods and increasing road traffic safety can be effective to address overweight and obesity among adolescents [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Overweight, Obesity, Central Obesity, and Type 2 Diabetes among Adolescents in Qatar: A Cross-Sectional Study

Cheema

Abraham

El-Nahas

et al. 2022

IJERPH

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Qatar has a high obesity and type 2 diabetes mellitus (T2DM) burden. This study aimed to (1) determine the prevalence of overweight, obesity, and T2DM in 13–17-year-old adolescents and (2) evaluate associations with adolescents’ lifestyle and breastfeeding history, parental weight, and familial T2DM history. A cross-sectional study (double-stage cluster sampling) was conducted in 2018–2020 using a self-administered parental and adolescent questionnaire. In the results, 23.4% of the adolescents (107/459) were overweight; 19.9% (91/459) were obese; and 37.6% (171/459) had evidence of central obesity. Random blood sugar (RBS) was suggestive of prediabetes (≥140 mg/dL) for 23 (5.0%) adolescents and T2DM (≥200 mg/dL) for none. In multivariable analysis, obesity was significantly associated with no breastfeeding (OR = 3.17, 95% CI: 1.09–9.26) compared to breastfed adolescents for ≥6 months, with first-degree family history of T2DM (OR = 2.27; 95% CI: 1.22–4.27), with maternal obesity (OR = 2.40; 95% CI: 1.01–5.70), and with acanthosis nigricans in adolescents (OR = 19.8; 95% CI: 8.38–46.9). Central obesity was significantly associated with maternal obesity (OR = 2.21; 95% CI: 1.14–4.27) and with acanthosis nigricans (OR = 3.67; 95% CI: 1.88–7.18). Acanthosis nigricans (OR = 4.06; 95% CI: 1.41–11.7) was the only factor associated with elevated RBS. Addressing future disease burden among adults in Qatar will require extensive health and well-being programs, focused on healthy lifestyles and behaviors such as nutritious diets, physical activity, stress management, and self-care.

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“…(Brites et al, 2017;Toth, 2003). As previously mentioned, RCT involves multiple steps, with the first being the promotion of cholesterol efflux from cells to HDL particles (Martin et al, 2022). The second and third steps are carried out by LCAT and CETP, respectively (Martin et al, 2022).…”

Section: Hdl Functionalitymentioning

confidence: 99%

High density lipoprotein as a therapeutic target: Focus on its functionality

ROSSO,

DAVICO,

CHIAPPE

et al. 2023

BIOCELL

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Cardiovascular diseases (CVDs) are the leading cause of death globally. CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease and rheumatic heart disease among other conditions. There are multiple independent risk factors for CVD, including hypertension, age, smoking, insulin resistance, elevated low-density lipoprotein cholesterol (LDL-C) levels, and triglyceride levels. LDL-C levels have traditionally been the target for therapies aimed at reducing CVD risk. High density lipoprotein (HDL) constitutes the only lipoprotein fraction with atheroprotective functions. Early HDL-targeted therapies have focused on increasing HDL-C levels. However, clinical trials have shown that raising HDL-C with niacin failed to achieve CVD reduction. A possible explanation for these findings is that these drugs could interfere with lipid metabolism and cause alterations in HDL structure and composition, leading to loss of functionality. As a result, targeting HDL-C levels would be insufficient to achieve CVD risk reduction, making HDL functionality a more desirable focus for HDL-directed therapies. There are several drugs which show the potential to improve HDL functionality. These drugs include molecules already approved for human use, such as statins and niacin, and particularly, compounds currently undergoing development such as apolipoprotein A-I mimetics and reconstituted HDL preparations. These therapies show promising potential to improve HDL functionality specifically. Future therapeutic strategies should incorporate HDL functionality as a main target of interest.

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Vascular inflammation and impaired reverse cholesterol transport and lipid metabolism in obese children and adolescents

Cited by 12 publications

References 69 publications

Diferencia en las distintas funciones de las lipoproteínas de alta densidad en respuesta a la infección por SARS-CoV-2

Diferencia en las distintas funciones de las lipoproteínas de alta densidad en respuesta a la infección por SARS-CoV-2

Assessment of Overweight, Obesity, Central Obesity, and Type 2 Diabetes among Adolescents in Qatar: A Cross-Sectional Study

High density lipoprotein as a therapeutic target: Focus on its functionality

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