Vascular Inflammation in Aging

Ungvári, Zoltán; Csiszár, Anna; Kaley, Gabor

doi:10.1007/s00059-004-2625-x

Cited by 71 publications

(54 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies in different tissues have shown that normal aging is associated with a pro-inflammatory, pro-oxidant state that may favor an exaggerated response to injury and degenerative diseases (Choi et al 2010;Csiszar et al 2003;Ungvari et al 2004) and that increased activity of local angiotensin via angiotensin II type 1 receptors is involved in agerelated degenerative diseases (Basso et al 2005;Mukai et al 2002). In agreement, we have recently observed an age-related increased angiotensin activity in the nigra that may increase the vulnerability of Fig.…”

Section: Discussionsupporting

confidence: 86%

“…It is known that angiotensin II, acting via type 1 receptors, is one of the most important known inducers of inflammation and oxidative stress in several tissues (Mattson and Maudsley 2009;Min et al 2009;Ruiz-Ortega et al 2001). Normal aging has been associated with a pro-inflammatory, pro-oxidant state that may favor an exaggerated response to injury and degenerative diseases (Choi et al 2010;Csiszar et al 2003;Ungvari et al 2004). In accordance with this, several recent studies have suggested the potential of inhibition of angiotensin for treatment of age-associated diseases and longevity (Benigni et al 2009(Benigni et al , 2010Mattson and Maudsley 2009;Nishiyama et al 2009).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson’s disease

Rodríguez‐Pallares

Parga

Joglar

et al. 2011

AGE

View full text Add to dashboard Cite

Recent studies have shown that reninangiotensin system overactivation is involved in the aging process in several tissues as well as in longevity and aging-related degenerative diseases by increasing oxidative damage and inflammation. We have recently shown that angiotensin II enhances dopaminergic degeneration by increasing levels of reactive oxygen species and neuroinflammation, and that there is an aging-related increase in angiotensin II activity in the substantia nigra in rats, which may constitute a major factor in the increased risk of Parkinson's disease with aging. The mechanisms involved in the above mentioned effects and particularly a potential angiotensin-mitochondria interaction have not been clarified. The present study revealed that activation of mitochondrial ATP-sensitive potassium channels [mitoK(ATP)] may play a major role in the angiotensin II-induced effects on aging and neurodegeneration. Inhibition of mitoK(ATP) channels with 5-hydroxydecanoic acid inhibited the increase in dopaminergic cell death induced by angiotensin II, as well as the increase in superoxide/superoxide-derived reactive oxygen species levels and the angiotensin II-induced decrease in the mitochondrial inner membrane potential in cultured dopaminergic neurons. The present study provides data for considering brain renin-angiotensin system and mitoK(ATP) channels as potential targets for protective therapy in agingassociated diseases such as Parkinson's disease.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson’s disease

Rodríguez‐Pallares

Parga

Joglar

et al. 2011

AGE

View full text Add to dashboard Cite

show abstract

“…35). Vascular aging is characterized by increased oxidative stress (11,13,35), associated with an enhanced rate of endothelial apoptosis (15) and vascular inflammation (51). Thus future studies should elucidate whether antioxidant, antiapoptotic, and anti-inflammatory actions of resveratrol contribute to its antiaging vasculoprotective effects in the elderly (35).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol increases vascular oxidative stress resistance

Ungvári¹,

Orosz²,

Rivera³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

Self Cite

205

146

View full text Add to dashboard Cite

Epidemiological studies suggest that Mediterranean diets rich in resveratrol are associated with reduced risk of coronary artery disease. However, the mechanisms by which resveratrol exerts its vasculoprotective effects are not completely understood. Because oxidative stress and endothelial cell injury play a critical role in vascular aging and atherogenesis, we evaluated whether resveratrol inhibits oxidative stress-induced endothelial apoptosis. We found that oxidized LDL and TNF-␣ elicited significant increases in caspase-3/7 activity in endothelial cells and cultured rat aortas, which were prevented by resveratrol pretreatment (10 Ϫ6 -10 Ϫ4 mol/l). The protective effect of resveratrol was attenuated by inhibition of glutathione peroxidase and heme oxygenase-1, suggesting a role for antioxidant systems in the antiapoptotic action of resveratrol. Indeed, resveratrol treatment protected cultured aortic segments and/or endothelial cells against increases in intracellular H 2O2 levels and H2O2-mediated apoptotic cell death induced by oxidative stressors (exogenous H 2O2, paraquat, and UV light). Resveratrol treatment also attenuated UV-induced DNA damage (comet assay). Resveratrol treatment upregulated the expression of glutathione peroxidase, catalase, and heme oxygenase-1 in cultured arteries, whereas it had no significant effect on the expression of SOD isoforms. Resveratrol also effectively scavenged H2O2 in vitro. Thus resveratrol seems to increase vascular oxidative stress resistance by scavenging H2O2 and preventing oxidative stress-induced endothelial cell death. We propose that the antioxidant and antiapoptotic effects of resveratrol, together with its previously described anti-inflammatory actions, are responsible, at least in part, for its cardioprotective effects. endothelial cell; comet assay; caloric restriction mimetics; apoptosis; polyphenol; heme oxygenase antioxidant EPIDEMIOLOGICAL STUDIES have shown that, in southern France and other Mediterranean territories, the morbidity and mortality of coronary artery disease is low, despite a diet rich in saturated fats and smoking habits (17,30). This unexpected epidemiological finding was termed the "French paradox." It has been proposed that resveratrol, an important constituent of Mediterranean diets, is involved in vasculoprotection. Resveratrol has been identified in more than 70 species of plants, including grapevines (Vitis vinifera), mulberries (Morus rubra), Vaccinum species, and peanuts (Arachis hypogea), and it is thought to have diverse antiatherogenic activities (42, 55-57, 60, 61), such as the inhibition of LDL oxidation (22) and platelet aggregation (46) and regulation of vascular smooth muscle proliferation (24 -26, 54). Recently, studies from this and other laboratories have shown that resveratrol inhibits endothelial activation and monocyte adhesion (12, 21, 39) and attenuates proinflammatory gene expression by inhibition of NF-B activation in coronary arterial endothelial cells (12).There is overwhelming evidence that oxidative stres...

show abstract

“…In blood vessels, the cell membrane-associated NAD(P)H oxidase is a significant source of ROS production, and an increased vascular NAD(P)H oxidase has been shown to contribute importantly to the symptoms of vascular aging, including increased O 2 Ϫ ⅐ production, decreased bioavailability of the vasodilator and anti-apoptotic NO (1,12,13,15,19,24,37), increased cardiac oxygen demand (1), and vascular inflammation (Ungvari Z, unpublished observation). EB fluorescence measurements revealed that both the endothelial and smooth muscle cells of NMR vessels produce O 2 Ϫ ⅐ (Fig.…”

Section: Discussionmentioning

confidence: 99%

Comparison of endothelial function, O₂⁻· and H₂O₂ production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice

Labinskyy

Csiszár

Orosz

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

Self Cite

View full text Add to dashboard Cite

vari. Comparison of endothelial function, O 2Ϫ ⅐ and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice. Am J Physiol Heart Circ Physiol 291: H2698 -H2704, 2006; doi:10.1152/ajpheart.00534.2006.-Vascular aging is characterized by decreased nitric oxide (NO) bioavailability, oxidative stress, and enhanced apoptotic cell death. We hypothesized that interspecies comparative assesment of vascular function among rodents with disparate longevity may offer insight into the mechanisms determining successful vascular aging. We focused on four rodents that show approximately an order of magnitude range in maximum longevity (ML). The naked mole rat (NMR; Heterocephalus glaber) is the longest-living rodent known (ML Ͼ 28 yr), Damara mole rats (DMRs, Cryptomys damarensis; ML ϳ 16 yr) and guinea pigs (GPs, Cavia porcellus; ML ϳ 6 yr) have intermediate longevity, whereas laboratory mice are short living (ML ϳ 3.5 yr). We compared interspecies differences in endothelial function, O 2 Ϫ ⅐ and H2O2 production, and resistance to apoptotic stimuli in blood vessels. Sensitivity to acetylcholine-induced, NO-mediated relaxation was smaller in carotid arteries from NMRs, GPs, and DMRs than in mouse vessels. Measurements of production of O 2 Ϫ ⅐ (lucigenin chemiluminescence and ethidium bromide fluorescence) and H2O2 (dichlorofluorescein fluorescence) showed that free radical production in vascular endothelial and smooth muscle cells is comparable in vessels of the three longer-living species and in arteries of shorter-living mice. In mouse arteries, H2O2 (from 10 Ϫ6 to 10 Ϫ3 mol/l) and heat exposure (42°C for 15-45 min) enhanced apoptotic cell death, as indicated by an increased DNA fragmentation rate and increased caspase 3/7 activity. In NMR vessels, only the highest doses of H2O2 enhanced apoptotic cell death, whereas heat exposure did not increase DNA fragmentation rate. Interspecies comparison showed there is a negative correlation between H2O2-induced apoptotic cell death and ML. Thus endothelial vasodilator function and vascular production of reactive oxygen species do not correlate with maximal lifespan, whereas increased lifespan potential is associated with an increased vascular resistance to proapoptotic stimuli. senescence; comparative biology; vascular disease; atherosclerosis; IN THE UNITED STATES, the number of persons aged Ն65 years is expected to increase from ϳ35 million in 2000 to an estimated 71 million in 2030 (according to the Center for Disease Control). Epidemiological studies suggest that aging of the vascular system is directly responsible for Ͼ50% of mortality and morbidity in these age groups. Despite the growing incidence of aging-induced coronary artery disease, stroke, and diabetic vasculopathy, the factors determining successful vascular aging are still poorly understood.Vascular aging is characterized by proatherogenic functional and phenotypic alterations, including impaired endothelial nitric oxide (NO) mediation, increased product...

show abstract

Vascular Inflammation in Aging

Cited by 71 publications

References 80 publications

Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson’s disease

Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson’s disease

Resveratrol increases vascular oxidative stress resistance

Comparison of endothelial function, O₂⁻· and H₂O₂ production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice

Contact Info

Product

Resources

About

Vascular Inflammation in Aging

Cited by 71 publications

References 80 publications

Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson’s disease

Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson’s disease

Resveratrol increases vascular oxidative stress resistance

Comparison of endothelial function, O2−· and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice

Contact Info

Product

Resources

About

Comparison of endothelial function, O₂⁻· and H₂O₂ production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice