Vascular Invasion Predicts Recurrence in Stage IA2-IB Lung Adenocarcinoma but not Squamous Cell Carcinoma

Graph attention-based fusion of pathology images and gene expression for prediction of cancer survival

“…For example, in the LUAD low-risk case, the FSM model more strongly highlighted the lepidic tumor histologic pattern compared to the more aggressive solid pattern [11, 14, 18]. In the LUAD high-risk case, the FSM model highlighted the aggressive solid tumor histologic pattern and the focus of vascular invasion [24, 34] associated with an unfavorable prognosis. In LUSC, there are a few known histologic patterns or features associated with prognosis, however, we observe that in the low-risk LUSC case, the model highlighted tumor regions with high immune infiltrate that may be important to the survival prediction.…”

Extracellular vesicle-associated microRNA signatures related to lymphovascular invasion in early-stage lung adenocarcinoma

“…LVI has prognostic significance in patients with resected lung cancer, especially adenocarcinoma, and reflects the tumor aggressiveness 1 – 7 . Local tumor invasion and entry of tumor cells into the vasculature occur at the early-stage of the metastatic cascade.…”

“…Finally, enrichment and pathway analyses of miR-30d-5p identified the correlated targeted genes, relevant enriched GO terms, and potential pathways involved in the occurrence of LVI in lung cancer. LVI has prognostic significance in patients with resected lung cancer, especially adenocarcinoma, and reflects the tumor aggressiveness [1][2][3][4][5][6][7] . Local tumor invasion and entry of tumor cells into the vasculature occur at the early-stage of the metastatic cascade.…”

“…Pathological lymphovascular invasion (LVI), which is the presence of vascular invasion and/or lymphatic permeation, is a strong prognostic factor in many types of cancer, including lung cancer 1 – 7 . The presence of LVI, which reflects tumor aggressiveness, is an essential step toward locoregional and systemic tumor spread.…”

Vascular invasion predicts the subgroup of lung adenocarcinomas ≤2.0 cm at risk of poor outcome treated by wedge resection compared to lobectomy

“… 4 We subsequently showed that vascular invasion is the most predictive histologic feature of aggressive lung adenocarcinoma and proposed the nomenclature of angioinvasive adenocarcinomas to distinguish them from squamous cell carcinomas whose behavior is not predicted by the routine histologic identification of vascular invasion. 5 , 6 In the present study, we sought to further evaluate the biological potential and diagnostic reproducibility of adenocarcinomas stratified by our novel approach compared with World Health Organization (WHO) grade, comparing outcomes of patients with adenocarcinoma ≤2.0 cm in total tumor size treated by lobectomy and those treated by wedge resection. Our objective was to identify histologic features of aggressive adenocarcinomas ≤2.0 cm for which wedge resection might be considered inadequate.…”