Vascular Lipoleiomyoma of the Uterus: an Unusual Case

Abstract

Introduction:Uterine lipoleiomyomas are a rare type of uterine myomas, which have been seldom diagnosed and are less known and still unusual. Histologically they are composed of smooth muscle cells with multiple fat cells and fibrous tissue. Their pathogenesis is still a stigmata and their preoperative diagnosis is still questionable.Case report history:A 39-year old woman presented at the University clinic for obstetrics and gynecology with complaints of a mild low abdominal and pelvic pain, increased frequency of vaginal bleeding and abdominal distension. Ultrasound examination showed dislocated uterus by a large semisolid tumor, located between the uterus and the urinary bladder. This mass was not well defined and had great vascularity. Pelvic computerized tomography revealed a large heterogeneous tumor located behind the bladder, measuring 8.5x7.5cm in size, making compression on the other pelvic organs.Conclusion:We should pay more attention on the preoperative imaging studies, in order to select patients who require surgery and further treatment more appropriately.

Inhibition of WNT/β-catenin signaling under serum starvation and hypoxia induces adipocytic transdifferentiation in human leiomyoma cells

“…The proportion of the fatty component within the lesion is highly variable and may be shown as an almost entirely fatty neoplasm simulating lipoma. Several pathogenetic mechanisms underlying the presence of fat cells within leiomyoma have been discussed previously [3][4][5]16]. Although the direct transformation (metaplasia or Our study demonstrated that adipocytic transdifferentiation, as shown by intracellular lipid accumulation and the enhanced expression of adipogenic markers (i.e., adiponectin, perilipin-1), can be elicited in cultured uterine leiomyoma cells by XAV939 treatment together with serum starvation and hypoxia.…”

“…The phenomenon is most commonly encountered in neoplastic conditions of smooth muscle cells such as leiomyomas and angiomyomas [1][2][3]. However, the detailed mechanisms underlying adipocytic transdifferentiation remain largely unknown; however, the adipocytic differentiation of pluripotent mesenchymal cells in such lesions and the direct transformation of neoplastic smooth muscle cells are possible explanations [3][4][5].…”