Vascular malformations

Garzon, María C.; Huang, Jennifer T.; Enjolras, O; Frieden, Ilona J.

doi:10.1016/j.jaad.2006.05.069

Cited by 308 publications

(275 citation statements)

References 132 publications

(125 reference statements)

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“…According to the most recent classification adopted by the International Society for the Study of Vascular Anomalies (ISSVA), these lesions are divided into true vascular tumors resulting from endothelial proliferation and vascular malformations resulting from defective embryonic vasculogenesis [1,9,10,25]. The majority of vascular anomalies follow a benign clinical course: For example, most children with infantile hemangioma (IH) typically experience a phase of proliferation during the first year of life followed by a phase of stabilization and spontaneous involution with complete resolution over the next years [10].…”

Section: Introductionmentioning

confidence: 99%

Sirolimus for the treatment of children with various complicated vascular anomalies

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Sirolimus for the treatment of children with various complicated vascular anomalies

et al. 2015

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“…In stage 3, destruction of the lesion or the underlying structures occurs. The final stage 4 is associated with cardiac decompensation due to high output cardiac failure 1, 2, 5, 6, 7. Traumatic AVMs are uncommon and occur in the setting of penetrating, blunt or postsurgical trauma.…”

Section: Discussionmentioning

confidence: 99%

Arteriovenous malformation after punch biopsy clinically mimicking a basal cell carcinoma: Case report and review of literature

Worm

Roberts

Isaacs

et al. 2018

Clinical Case Reports

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“…Venous malformations may be noted at birth or they may manifest during childhood or adolescence. Arteriovenous malformations are often visible at birth but display their highflow signs characteristically during childhood or adolescence [8,9].…”

Section: Introductionmentioning

confidence: 99%

Vascular malformations in infancy and young adulthood: signs and symptoms signaling progression

et al. 2012

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Background: Vascular malformations (VMFs) are errors in the embryonic development of vessels and are always present at birth, but not necessarily visible or symptomatic. VMFs grow or dilate proportionally with the child and sometimes expand suddenly. They often get symptomatic at a later moment in life, mostly during childhood or adolescence.Objective: The objective is to elucidate the natural history of VMFs in children and young adults and to figure out how they are influenced in order to predict the course of the condition, to inform patients, parents and physicians about what awaits them and how they could possibly avoid progression or at least, be prepared to handle it.Methods: 51 patients displaying different types of vascular malformations at the Vascular Anomalies Center at the Medical University Vienna were included in this study. They were interviewed by questionnaire about the course of their disease, symptoms and possible triggers.Results: The patient collective was composed of 25 male and 26 female patients between 4 and 66 years of age. 37 had a slow-flow malformation (with capillary, venous or lymphatic components), 14 had a fast-flow malformation. Most of the malformations (64%) were localized on the extremities. 51% of them had their onset at birth, 37% in the first 20 years of life, only 12% later than 20 years of age. Symptoms at onset were swelling (75%), pain (45%), functional impairment (43%), skin discoloration (39%) and bleeding (6%). Some patients also experienced local infection at a later moment. 62% of the VMFs grew proportionally with age, 38% of the patients experienced a sudden progression of the lesion. Patients were classified into 4 growth patterns: 31% in 1a (onset at birth, proportional growth), 20% in 1b (onset at birth, progression), 31% in 2a (onset later, proportional growth) and 18% in 2b (onset later, progression). Factors related to onset and progression were puberty (24%), surgery (8%), trauma (6%) and pregnancy (4%). Factors that worsened the symptoms temporarily were exercise (78%), trauma (41%), heat (25%), stress (18%), illness (18%), cold (16%), pregnancy (8%) and hormonal contraceptives (6%).Conclusions: Due to the small group of patients and the diversity of vascular malformations, not all results were statistically relevant. Nonetheless, an epidemiologic overview is given and a contribution towards elucidation of the natural course of vascular malformations is provided.

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Vascular malformations

Cited by 308 publications

References 132 publications

Sirolimus for the treatment of children with various complicated vascular anomalies

Sirolimus for the treatment of children with various complicated vascular anomalies

Arteriovenous malformation after punch biopsy clinically mimicking a basal cell carcinoma: Case report and review of literature

Vascular malformations in infancy and young adulthood: signs and symptoms signaling progression

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