Vascular Malformations and Their Treatment in the Growing Patient

Kolokythas, Antonia

doi:10.1016/j.coms.2015.07.006

Cited by 11 publications

(14 citation statements)

References 82 publications

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“…The local injection of a sclerosing substance inside a hemangioma or venous malformation determines the onset of inflammatory changes and detachment of endothelial cells that eventually determine vessel thrombosis and occlusion, sclerosis and involution of the lesion (9)(10)(11). Considering the depth of the lesion, the injections can be performed by imaging guidance, including fluoroscopic or ultrasound examination (2,3). Embolization can be performed before the local injection of sclerosing agent in order to prevent the systemic spread of the substance and to ensure prolonged local action, especially in combined malformations.…”

Section: Sclerotherapymentioning

confidence: 99%

“…The indications for using bleomycin as a sclerosing agent follow the same criteria as for performing sclerotherapy in general, with the specification that using bleomycin may be more advantageous in certain situations, as compared to other substances associated with more complications (2,7,20). In other words, it is advisable to prefer bleomycin to other agents whenever it is considered critical to avoid certain known complications that may even endanger the patient's life or cause important functional impairment.…”

Section: Indications and Outcomes Of Bleomycin Sclerotherapymentioning

confidence: 99%

“…Vascular anomalies have the greatest frequency in the head and neck areas and are often encountered in children (1,2). An accurate minimally invasive treatment of this condition is particularly important, considering the predominant age group, the potentially severe complications and debilitating sequelae.…”

Section: Introductionmentioning

confidence: 99%

“…The choice is made according to the age of the patient, the size of the lesion and the expected rate of progression, the anatomical segment involved, the symptoms, as well as the presence or potential for aesthetic and functional impairment or complications (2,3,6).…”

Section: Introductionmentioning

confidence: 99%

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Management of head and neck hemangiomas and venous malformations by bleomycin sclerotherapy

Dragomir¹,

Ciofu²,

Doscas³

et al. 2020

Ro Med J.

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ManageMent of head and neck heMangioMas and venous MalforMations by bleoMycin sclerotherapy lecturer raluca a. dragomir 1 , Md, phd, lecturer Mihai liviu ciofu 1 , Md, phd, assist. prof. andrada doscas 1 , Md, phd, assist. prof. alexandra carp 1 , Md, phd, lecturer bogdan dragomir 2 , Md, phd, nicolae dobrin 3 , Md, lecturer otilia boisteanu 1 , Md, phd, associate prof. victor-vlad costan 1 , Md, phd

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Section: Sclerotherapymentioning

confidence: 99%

Section: Indications and Outcomes Of Bleomycin Sclerotherapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Management of head and neck hemangiomas and venous malformations by bleomycin sclerotherapy

Dragomir¹,

Ciofu²,

Doscas³

et al. 2020

Ro Med J.

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“…4), neuronal migration defects, and polymicrogyria, which are frequent in Proteus syndrome but also described in CLOVES patients who did not meet the diagnostic criteria for Proteus syndrome (24)(25)(26). The clinical manifestations of these disorders include mental retardation and, especially, epileptiform symptoms (15,24).…”

Section: Neurological Disordersmentioning

confidence: 99%

CLOVES syndrome: review of a PIK3CA‐related overgrowth spectrum (PROS)

et al. 2016

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Overgrowth syndromes are characterized by global or localized disproportionate growth associated with other anomalies, including vascular malformations and neurological and/or visceral disorders. CLOVES (Congenital Lipomatous asymmetric Overgrowth of the trunk with lymphatic, capillary, venous, and combined-type Vascular malformations, Epidermal naevi, Scoliosis/Skeletal and spinal anomalies) is an overgrowth syndrome caused by mosaic activating mutation in gene PIK3CA, which gives rise to abnormal PI3K-AKT-mTOR pathway activation. These mutations are responsible for the clinical manifestations of the syndrome, which include low- and high-flow vascular malformations, thoracic lipomatous hyperplasia, asymmetric growth, and visceral and neurological disorders. These common anomalies are illustrated with figures from two personal cases. Identification of the clinical and genetic characteristics of CLOVES syndrome is crucial for the differential diagnosis with other overgrowth syndromes, such as Proteus or Klippel-Trenaunay (K-T) syndromes, and for the therapeutic management of the different anomalies. In this context, a new entity comprising different syndromes with phenotypic mutations in PIK3CA has been proposed, designated PIK3CA-related overgrowth spectrum (PROS), with the aim of facilitating clinical management and establishing appropriate genetic study criteria.

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