Vascular Mechanisms in Spinal Cord Injury

Hagg, Theo

doi:10.1007/978-1-4614-8690-9_9

Cited by 1 publication

(1 citation statement)

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“…In this work, while stimulated pericytes promoted greater vascular density in males, this did not result in increased NF density or improved BBB scores The process of angiogenesis can result in an initially unstable and immature vascular bed 7,44 . An acute vascular pathology of clinical concern in SCI is hemorrhage and blood‐spinal cord barrier disruption 45,46 . The increase in blood flow and vascular density seen in male rats injected with stimulated pericytes could negatively affect a tissue in which the blood‐spinal cord barrier is not intact.…”

Section: Discussionmentioning

confidence: 67%

Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats

et al. 2020

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Objective It is not known how activation of the hypoxia‐inducible factor (HIF) pathway in pericytes, cells of the microvascular wall, influences new capillary growth. We tested the hypothesis that HIF‐activated pericytes promote angiogenesis in a neonatal model of spinal cord injury (SCI). Methods Human placental pericytes stimulated with cobalt chloride and naïve pericytes were injected into the site of a thoracic hemi‐section of the spinal cord in rat pups on postnatal day three (P3). Hindlimb motor recovery and Doppler blood flow perfusion at the site of transection were measured on P10. Immunohistochemistry was used to visualize vessel and neurofilament density for quantification. Results Injection of HIF‐activated pericytes resulted in greater vascular density in males but did not result in improved motor function for males or females. Injection of non–HIF‐activated pericytes resulted improved motor function recovery in both sexes (males, 2.722 ± 0.31‐fold score improvement; females, 3.824 ± 0.58‐fold score improvement, P < .05) but produced no significant changes in vessel density. Conclusions HIF‐activated pericytes promote vascular density in males post‐SCI. Acute delivery of non–HIF‐activated pericytes at the site of injury can improve motor recovery post‐SCI.

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Section: Discussionmentioning

confidence: 67%